Literature DB >> 24637084

Project for the development of the linac based NCT facility in University of Tsukuba.

H Kumada1, A Matsumura2, H Sakurai3, T Sakae3, M Yoshioka4, H Kobayashi4, H Matsumoto4, Y Kiyanagi5, T Shibata6, H Nakashima6.   

Abstract

A project team headed by University of Tsukuba launched the development of a new accelerator based BNCT facility. In the project, we have adopted Radio-Frequency Quadrupole (RFQ)+Drift Tube Linac (DTL) type linac as proton accelerators. Proton energy generated from the linac was set to 8MeV and average current was 10mA. The linac tube has been constructed by Mitsubishi Heavy Industry Co. For neutron generator device, beryllium is selected as neutron target material; high intensity neutrons are generated by the reaction with beryllium and the 80kW proton beam. Our team chose beryllium as the neutron target material. At present beryllium target system is being designed with Monte-Carlo estimations and heat analysis with ANSYS. The neutron generator consists of moderator, collimator and shielding. It is being designed together with the beryllium target system. We also acquired a building in Tokai village; the building has been renovated for use as BNCT treatment facility. It is noteworthy that the linac tube had been installed in the facility in September 2012. In BNCT procedure, several medical devices are required for BNCT treatment such as treatment planning system, patient positioning device and radiation monitors. Thus these are being developed together with the linac based neutron source. For treatment planning system, we are now developing a new multi-modal Monte-Carlo treatment planning system based on JCDS. The system allows us to perform dose estimation for BNCT as well as particle radiotherapy and X-ray therapy. And the patient positioning device can navigate a patient to irradiation position quickly and properly. Furthermore the device is able to monitor movement of the patient׳s position during irradiation.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Accelerator based BNCT; Accelerator based neutron source; Beryllium target; Linac; Treatment planning system

Mesh:

Year:  2014        PMID: 24637084     DOI: 10.1016/j.apradiso.2014.02.018

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN: 0969-8043            Impact factor:   1.513


  5 in total

Review 1.  Boron neutron capture therapy for malignant brain tumors.

Authors:  Shin-Ichi Miyatake; Masahiko Wanibuchi; Naonori Hu; Koji Ono
Journal:  J Neurooncol       Date:  2020-07-16       Impact factor: 4.130

2.  Evaluation of radioactivity in the bodies of mice induced by neutron exposure from an epi-thermal neutron source of an accelerator-based boron neutron capture therapy system.

Authors:  Satoshi Nakamura; Shoji Imamichi; Kazuyoshi Masumoto; Masashi Ito; Akihisa Wakita; Hiroyuki Okamoto; Shie Nishioka; Kotaro Iijima; Kazuma Kobayashi; Yoshihisa Abe; Hiroshi Igaki; Kazuyoshi Kurita; Teiji Nishio; Mitsuko Masutani; Jun Itami
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2017       Impact factor: 3.493

3.  Enlargement of a Modular System-Synthesis and Characterization of an s-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load.

Authors:  Martin Kellert; Peter Lönnecke; Bernd Riedl; Johannes Koebberling; Evamarie Hey-Hawkins
Journal:  Molecules       Date:  2019-09-10       Impact factor: 4.411

4.  Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target.

Authors:  Satoshi Nakamura; Hiroshi Igaki; Masashi Ito; Hiroyuki Okamoto; Shie Nishioka; Kotaro Iijima; Hiroki Nakayama; Mihiro Takemori; Shoji Imamichi; Tairo Kashihara; Kana Takahashi; Koji Inaba; Kae Okuma; Naoya Murakami; Yoshihisa Abe; Yuko Nakayama; Mitsuko Masutani; Teiji Nishio; Jun Itami
Journal:  PLoS One       Date:  2019-11-22       Impact factor: 3.240

Review 5.  Boron neutron capture therapy: Current status and future perspectives.

Authors:  Mayya Alexandrovna Dymova; Sergey Yurjevich Taskaev; Vladimir Alexandrovich Richter; Elena Vladimirovna Kuligina
Journal:  Cancer Commun (Lond)       Date:  2020-08-17
  5 in total

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