Yuri Milaneschi1, Angelina R Sutin2, Antonio Terracciano3, Marco Canepa4, Kristofer S Gravenstein5, Josephine M Egan6, Nicole Vogelzangs7, Jack M Guralnik8, Stefania Bandinelli9, Brenda W J H Penninx7, Luigi Ferrucci5. 1. Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA. Electronic address: y.milaneschi@ggzingeest.nl. 2. Department of Medical Humanities and Social Sciences, Florida State University College of Medicine, Tallahassee, FL, USA; Laboratory of Population Science, National Institute on Aging, Baltimore, MD, USA. 3. Department of Geriatrics Florida State University College of Medicine, Tallahassee, FL, USA. 4. Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA; Laboratory of Cardiovascular Sciences, Human Cardiovascular Studies Unit, National Institute on Aging, Baltimore, MD, USA; Department of Internal Medicine, University of Genova, Genova, Italy. 5. Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA. 6. Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA; Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA. 7. Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands. 8. University of Maryland School of Medicine, Baltimore, MD, USA. 9. Geriatric Unit, ASF, Florence, Italy.
Abstract
BACKGROUND: Evidence for a role of leptin in depression is limited and conflicting. Inconclusive findings may be explained by the complex effect of obesity on leptin signaling. In particular, both hyperleptinemia due to leptin resistance in obese persons as well as low leptin in lean persons can imply that low leptin biological signaling is associated with an increased risk of significant depressive symptoms. We tested whether the relationship between leptin and depressive symptoms is modulated by abdominal adiposity in two population-based studies. METHODS: Data were from 851 participants (65-94 years) of the InCHIANTI Study and 1064 (26-93 years) of the Baltimore Longitudinal Study of Aging (BLSA). Plasma concentrations of leptin, waist circumference and depressive symptoms via the Center for Epidemiological Studies-Depression scale (CES-D) were assessed. In longitudinal InCHIANTI analyses onset of depressed mood (CES-D≥20) was evaluated over a 9-year follow-up. RESULTS: In pooled cross-sectional analyses the interaction between leptin and waist circumference was significantly associated with CES-D scores ((log)leptin-by-waist interaction p=0.01). Also in longitudinal analyses, the (log)leptin-by-waist interaction term significantly (p=0.04) predicted depressed mood onset over time; depressed mood risk was especially increased for high levels of both leptin and waist circumference. CONCLUSIONS: The present findings suggest that low leptin signaling rather than low leptin concentration is a risk factor for depression. Future studies should develop proxy measures of leptin signaling by combining information on abdominal adiposity and leptin level to be used for clinical and research applications.
BACKGROUND: Evidence for a role of leptin in depression is limited and conflicting. Inconclusive findings may be explained by the complex effect of obesity on leptin signaling. In particular, both hyperleptinemia due to leptin resistance in obesepersons as well as low leptin in lean persons can imply that low leptin biological signaling is associated with an increased risk of significant depressive symptoms. We tested whether the relationship between leptin and depressive symptoms is modulated by abdominal adiposity in two population-based studies. METHODS: Data were from 851 participants (65-94 years) of the InCHIANTI Study and 1064 (26-93 years) of the Baltimore Longitudinal Study of Aging (BLSA). Plasma concentrations of leptin, waist circumference and depressive symptoms via the Center for Epidemiological Studies-Depression scale (CES-D) were assessed. In longitudinal InCHIANTI analyses onset of depressed mood (CES-D≥20) was evaluated over a 9-year follow-up. RESULTS: In pooled cross-sectional analyses the interaction between leptin and waist circumference was significantly associated with CES-D scores ((log)leptin-by-waist interaction p=0.01). Also in longitudinal analyses, the (log)leptin-by-waist interaction term significantly (p=0.04) predicted depressed mood onset over time; depressed mood risk was especially increased for high levels of both leptin and waist circumference. CONCLUSIONS: The present findings suggest that low leptin signaling rather than low leptin concentration is a risk factor for depression. Future studies should develop proxy measures of leptin signaling by combining information on abdominal adiposity and leptin level to be used for clinical and research applications.
Authors: Y Oomura; N Hori; T Shiraishi; K Fukunaga; H Takeda; M Tsuji; T Matsumiya; M Ishibashi; S Aou; X L Li; D Kohno; K Uramura; H Sougawa; T Yada; M J Wayner; K Sasaki Journal: Peptides Date: 2006-08-17 Impact factor: 3.750
Authors: Floriana S Luppino; Leonore M de Wit; Paul F Bouvy; Theo Stijnen; Pim Cuijpers; Brenda W J H Penninx; Frans G Zitman Journal: Arch Gen Psychiatry Date: 2010-03
Authors: Gregory E Miller; Kenneth E Freedland; Robert M Carney; Cinnamon A Stetler; William A Banks Journal: Brain Behav Immun Date: 2003-08 Impact factor: 7.217
Authors: Yuri Milaneschi; Anna Maria Corsi; Brenda W Penninx; Stefania Bandinelli; Jack M Guralnik; Luigi Ferrucci Journal: Biol Psychiatry Date: 2008-12-25 Impact factor: 13.382
Authors: Yuri Milaneschi; Femke Lamers; Wouter J Peyrot; Bernhard T Baune; Gerome Breen; Abbas Dehghan; Andreas J Forstner; Hans J Grabe; Georg Homuth; Carol Kan; Cathryn Lewis; Niamh Mullins; Matthias Nauck; Giorgio Pistis; Martin Preisig; Margarita Rivera; Marcella Rietschel; Fabian Streit; Jana Strohmaier; Alexander Teumer; Sandra Van der Auwera; Naomi R Wray; Dorret I Boomsma; Brenda W J H Penninx Journal: JAMA Psychiatry Date: 2017-12-01 Impact factor: 21.596
Authors: W Kyle Simmons; Kaiping Burrows; Jason A Avery; Kara L Kerr; Ashlee Taylor; Jerzy Bodurka; William Potter; T Kent Teague; Wayne C Drevets Journal: Mol Psychiatry Date: 2018-06-13 Impact factor: 15.992