Hugo Morales-Briceño1, Mayela Rodríguez-Violante2, Daniel Martinez-Ramirez3, Amin Cervantes-Arriaga2. 1. Department of Neurology, Instituto Nacional de Neurología y Neurocirugía, México, Mexico; Movement Disorders Clinic, Instituto Nacional de Neurología y Neurocirugía, México, Mexico. Electronic address: moralhu@gmail.com. 2. Clinical Neurodegenerative Disease Research Unit, Instituto Nacional de Neurología y Neurocirugía, México, Mexico; Movement Disorders Clinic, Instituto Nacional de Neurología y Neurocirugía, México, Mexico. 3. Movement Disorders Clinic, Instituto Nacional de Neurología y Neurocirugía, México, Mexico.
Abstract
INTRODUCTION: Gait abnormalities are prominent in atypical parkinsonian disorders and clinical signs such abnormal tandem walk have been suggested as a red flag for differential diagnosis. The objective is to determine the sensibility and specificity of the ten-steps test to discriminate atypical parkinsonisms from Parkinson's disease. METHODS: A sample of subjects with a parkinsonian disorder was evaluated. The ten-steps test was applied to all subjects. A Bayesian analysis model was used to calculate sensibility and specificity. RESULTS: A total of 32 subjects with atypical parkinsonism and 54 subjects with Parkinson's disease were included. Abnormal tandem gait had a sensitivity of 90.6% and specificity of 66.6% to differentiate between groups. When adjusted to the actual atypical parkinsonism prevalence the positive predictive value fall from 61.7% to 13.8%. CONCLUSION: The ten-steps test provides additional information for the differential diagnosis in parkinsonian disorders but can only be regarded as a red flag. Crown
INTRODUCTION: Gait abnormalities are prominent in atypical parkinsonian disorders and clinical signs such abnormal tandem walk have been suggested as a red flag for differential diagnosis. The objective is to determine the sensibility and specificity of the ten-steps test to discriminate atypical parkinsonisms from Parkinson's disease. METHODS: A sample of subjects with a parkinsonian disorder was evaluated. The ten-steps test was applied to all subjects. A Bayesian analysis model was used to calculate sensibility and specificity. RESULTS: A total of 32 subjects with atypical parkinsonism and 54 subjects with Parkinson's disease were included. Abnormal tandem gait had a sensitivity of 90.6% and specificity of 66.6% to differentiate between groups. When adjusted to the actual atypical parkinsonism prevalence the positive predictive value fall from 61.7% to 13.8%. CONCLUSION: The ten-steps test provides additional information for the differential diagnosis in parkinsonian disorders but can only be regarded as a red flag. Crown