Literature DB >> 24633688

Is the interleukin 8 promoter polymorphism rs4073/-251T >A associated with Clostridium difficile infection?

Fabio Miyajima1, Andrew Swale1, J Eunice Zhang2, Ana Alfirevic2, Margaret Little1, Nicholas J Beeching3, Godfrey Smith4, Ruwanthi Kolamunnage-Dona5, Munir Pirmohamed1.   

Abstract

The interleukin 8 gene single-nucleotide polymorphism rs4073/-251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been independently validated. In this study, we were unable to replicate this association in either a white cohort or by meta-analysis, suggesting that rs4073/-251T >A is unlikely to constitute a major risk factor for CDI.
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Clostridium difficile; genetic predisposition; host response; interleukin 8; meta-analysis

Mesh：

Substances：

Year:  2014        PMID： 24633688     DOI： 10.1093/cid/ciu152

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  4 in total

1.  Recurrent Clostridium difficile Infection in Children: Patient Risk Factors and Markers of Intestinal Inflammation.

Authors:  Maribeth R Nicholson; Jonathan D Crews; Jeffrey R Starke; Zhi-Dong Jiang; Herbert DuPont; Kathryn Edwards
Journal:  Pediatr Infect Dis J       Date:  2017-04       Impact factor: 2.129

2.  Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records.

Authors:  Jiang Li; Yanfei Zhang; Alexandria L Jilg; Donna M Wolk; Harshit S Khara; Amy Kolinovsky; David D K Rolston; Raquel Hontecillas; Josep Bassaganya-Riera; Marc S Williams; Vida Abedi; Ming Ta Michael Lee
Journal:  Front Immunol       Date:  2021-03-25       Impact factor: 7.561

3.  Serum mannose-binding lectin concentration, but not genotype, is associated with Clostridium difficile infection recurrence: a prospective cohort study.

Authors:  Andrew Swale; Fabio Miyajima; Ruwanthi Kolamunnage-Dona; Paul Roberts; Margaret Little; Nicholas J Beeching; Mike B J Beadsworth; Triantafillos Liloglou; Munir Pirmohamed
Journal:  Clin Infect Dis       Date:  2014-08-28       Impact factor: 9.079

4.  Genetic Association Reveals Protection against Recurrence of Clostridium difficile Infection with Bezlotoxumab Treatment.

Authors:  Judong Shen; Devan V Mehrotra; Mary Beth Dorr; Zhen Zeng; Junhua Li; Xun Xu; David Nickle; Emily R Holzinger; Aparna Chhibber; Mark H Wilcox; Rebecca L Blanchard; Peter M Shaw
Journal:  mSphere       Date:  2020-05-06       Impact factor: 4.389
  4 in total

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