| Literature DB >> 24631976 |
J W Chang1, C Y Chen, B R Yan2, M H Chang3, S H Tseng3, Y M Kao3, J C Chen4, C C Lee5.
Abstract
Phthalates strongly and adversely affect reproduction, development and liver function. We did a cumulative risk assessment for simultaneous exposure to nine phthalates using the hazard index (HI) and the levels of nine phthalates in 1200 foodstuff samples. DEHP (di-2-ethylhexyl phthalate) present the highest level (mean: 0.443 mg/kg) in 1200 samples, and the highest average daily dose (ADD) was found in DEHP, ΣDBP(i + n) (the sum of dibutyl phthalate [DBP] isomers [DnBP + DiBP]) posed the highest risk potential of all the phthalates. In seven phthalates, the 95th percentiles of the ADDs for ΣDBP(i + n) in 0-6-yr-old children accounted for 91% (79-107%) of the tolerable daily intake, and the 95th percentiles of the HIs for the anti-androgenic effects of five phthalates in 0-3-yr-old children and 4-6-yr-old girls were >1. We conclude that the health of younger Taiwanese may be adversely affected by overexposure of phthalate-contaminated foods.Entities:
Keywords: Average daily dose; Cumulative risk assessment; Hazard index; Phthalate esters; Plasticizer-contaminated food
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Year: 2014 PMID： 24631976 DOI： 10.1016/j.envpol.2014.02.005
Source DB: PubMed Journal: Environ Pollut ISSN： 0269-7491 Impact factor: 8.071