| Literature DB >> 24631782 |
Christos G Mihos1, Andres M Pineda1, Orlando Santana2.
Abstract
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, better known as 'statins', are amongst the most widely used medications in the world. They have become a pivotal component in the primary and secondary prevention of coronary artery and vascular disease. However, a growing amount of evidence has suggested that statins also possess strong pleiotropic effects irrespective of their lipid-lowering properties, which include enhancement of endothelial function, anti-inflammatory and anti-atherothrombotic properties, and immunomodulation. The following provides a comprehensive and updated review of the clinical evidence regarding the pleiotropic effects of statins in cardiovascular disorders and their potential therapeutic benefits.Entities:
Keywords: 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors; Cardiovascular disorders; Pleiotropic effects; Statins
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Year: 2014 PMID： 24631782 DOI： 10.1016/j.phrs.2014.02.009
Source DB: PubMed Journal: Pharmacol Res ISSN： 1043-6618 Impact factor: 7.658