| Literature DB >> 24631766 |
Shi-Lin Luo1, Xiao-Jun Huang2, Ying Wang2, Ren-Wang Jiang3, Lei Wang2, Liang-Liang Bai3, Qun-Long Peng3, Cai-Lu Song2, Dong-Mei Zhang4, Wen-Cai Ye5.
Abstract
Four new isocoumarins (1-4), along with three known ones (5-7), were isolated from the 70% ethanol extract of the whole body of the traditional Chinese insect medicine, American cockroach (Periplaneta americana). The structures with absolute configurations of new compounds were elucidated by extensive spectroscopic methods in combination with X-ray diffraction experiment and CD analyses. Compounds 3-5 showed significant cytotoxic activities in HepG2 and MCF-7 cells with IC50 values in the ranges 6.41-23.91 μM and 6.67-39.07 μM, respectively.Entities:
Keywords: American cockroach; Cytotoxicity; Isocoumarin; Periplaneta americana
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Year: 2014 PMID： 24631766 DOI： 10.1016/j.fitote.2014.03.004
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882