Literature DB >> 24631765

Phytochemical investigation of sesquiterpenes from the fruits of Schisandra chinensis and their cytotoxic activity.

A Venkanna1, B Siva1, B Poornima1, P R Rao Vadaparthi1, K Rajendra Prasad1, K Ashok Reddy2, G Bhanu Prakash Reddy2, K Suresh Babu3.   

Abstract

Phytochemical investigation of ethanolic extract from the fruits of Schisandra chinensis led to the isolation of four new sesquiterpenes (1-4); their structures were determined by a combination of NMR (1D and 2D) and MS spectroscopic techniques. In addition, all these isolates were screened for their cytotoxic activities against MCF-7, Caco-2, Hela, Lncap, Hep G2 and MDA-MB231 cancer cell lines. Results indicated that compounds 2 and 3 displayed potent cytotoxic activity against Caco2 cell lines with IC50 values of 17.10 μg/mM and 16.46 μg/mM, respectively.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cytotoxic activity; Schisandra chinensis; Schisandraceae; Sesquiterpenes

Mesh：

Substances：

Year:  2014        PMID： 24631765     DOI： 10.1016/j.fitote.2014.03.003

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  6 in total

Review 1.  Herbals and Plants in the Treatment of Pancreatic Cancer: A Systematic Review of Experimental and Clinical Studies.

Authors:  John K Triantafillidis; Eleni Triantafyllidi; Michail Sideris; Theodoros Pittaras; Apostolos E Papalois
Journal:  Nutrients       Date:  2022-01-30       Impact factor: 5.717

2.  Polyphenol-rich extract of Salvia chinensis exhibits anticancer activity in different cancer cell lines, and induces cell cycle arrest at the G₀/G₁-phase, apoptosis and loss of mitochondrial membrane potential in pancreatic cancer cells.

Authors:  Quan Zhao; Xue-Chen Huo; Fu-Dong Sun; Rui-Qian Dong
Journal:  Mol Med Rep       Date:  2015-07-13       Impact factor: 2.952

3.  The Chemical Composition and Functional Properties of Essential Oils from Four Species of Schisandra Growing Wild in the Qinling Mountains, China.

Authors:  Xiaorui Wang; Yan Liu; Yuanyuan Niu; Nongxue Wang; Wei Gu
Journal:  Molecules       Date:  2018-07-05       Impact factor: 4.411

Review 4.  Potential of Schisandra chinensis (Turcz.) Baill. in Human Health and Nutrition: A Review of Current Knowledge and Therapeutic Perspectives.

Authors:  Adriana Nowak; Małgorzata Zakłos-Szyda; Janusz Błasiak; Agnieszka Nowak; Zhuo Zhang; Bolin Zhang
Journal:  Nutrients       Date:  2019-02-04       Impact factor: 5.717

5.  A Homogeneous Polysaccharide from Fructus Schisandra chinensis (Turz.) Baill Induces Mitochondrial Apoptosis through the Hsp90/AKT Signalling Pathway in HepG2 Cells.

Authors:  Yonglin Chen; Songshan Shi; Huijun Wang; Ning Li; Juan Su; Guixin Chou; Shunchun Wang
Journal:  Int J Mol Sci       Date:  2016-06-28       Impact factor: 5.923

6.  Pharmacokinetics of Schizandrin and Its Pharmaceutical Products Assessed Using a Validated LC-MS/MS Method.

Authors:  Chi-Lin Li; Yung-Yi Cheng; Chen-Hsi Hsieh; Tung-Hu Tsai
Journal:  Molecules       Date:  2018-01-15       Impact factor: 4.411
  6 in total

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