Eunjeong Kim1, Hyesook Park1, Yun-Chul Hong2, Mina Ha3, Yangho Kim4, Boong-Nyun Kim5, Yeni Kim6, Young-Man Roh7, Bo-Eun Lee8, Jung-Min Ryu8, Byung-Mi Kim1, Eun-Hee Ha9. 1. Department of Preventive Medicine, Ewha Medical Research Center, Ewha Womans University, Seoul, South Korea. 2. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea. 3. Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan, South Korea. 4. Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea. 5. Division of Child & Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea. 6. Department of Adolescent Psychiatry, National Center for Child and Adolescent Psychiatry, Seoul National Hospital, Seoul, South Korea. 7. Institute for Environmental Research, Yonsei University, Seoul, South Korea. 8. Environmental Health Research Division, National Institute of Environmental Research, Incheon, South Korea. 9. Department of Preventive Medicine, Ewha Medical Research Center, Ewha Womans University, Seoul, South Korea. Electronic address: eunheeha@ewha.ac.kr.
Abstract
INTRODUCTION: Previous studies have suggested adverse effects of maternal exposure to air pollution on neurodevelopment in early childhood. OBJECTIVES: We aimed to investigate the association between prenatal exposure to particulates of less than 10 μm in diameter (PM10) and nitrogen dioxide (NO2) and neurodevelopment in children during the first 24 months of their lives. METHODS: The MOCEH study is a prospective birth cohort study in South Korea. Average exposure levels to PM10 and NO2 during the entire pregnancy were estimated using the inverse distance weighting (IDW) method. A total of 520 mother-child pairs who completed neurodevelopmental assessments using the Korean Bayley Scale of Infant Development II (K-BSID-II) more than once at ages of 6, 12 and 24 months were included. Mental developmental index (MDI) and psychomotor developmental index (PDI) from the K-BSID-II were used as outcome variables. RESULTS: There were negative associations between maternal exposure to PM10 and MDI (β=-2.83; p=0.003) and PDI (β=-3.00; p=0.002) throughout the first 24 months of life as determined by the generalized estimating equation (GEE) model. Maternal NO2 exposure was related with impairment of psychomotor development (β=-1.30; p=0.05) but not with cognitive function (β=-0.84; p=0.20). In a multiple linear regression model, there were significant effects of prenatal air pollution exposure on MDI (PM10: β=-4.60; p<0.001, NO2: β=-3.12; p<0.001) and PDI (PM10: β=-7.24; p<0.001, NO2: β=-3.01; p<0.001) at 6 months, but no significant association was found at 12 and 24 months of age. CONCLUSIONS: The findings suggest that exposure to air pollution may result in delayed neurodevelopment in early childhood.
INTRODUCTION: Previous studies have suggested adverse effects of maternal exposure to air pollution on neurodevelopment in early childhood. OBJECTIVES: We aimed to investigate the association between prenatal exposure to particulates of less than 10 μm in diameter (PM10) and nitrogen dioxide (NO2) and neurodevelopment in children during the first 24 months of their lives. METHODS: The MOCEH study is a prospective birth cohort study in South Korea. Average exposure levels to PM10 and NO2 during the entire pregnancy were estimated using the inverse distance weighting (IDW) method. A total of 520 mother-child pairs who completed neurodevelopmental assessments using the Korean Bayley Scale of Infant Development II (K-BSID-II) more than once at ages of 6, 12 and 24 months were included. Mental developmental index (MDI) and psychomotor developmental index (PDI) from the K-BSID-II were used as outcome variables. RESULTS: There were negative associations between maternal exposure to PM10 and MDI (β=-2.83; p=0.003) and PDI (β=-3.00; p=0.002) throughout the first 24 months of life as determined by the generalized estimating equation (GEE) model. Maternal NO2 exposure was related with impairment of psychomotor development (β=-1.30; p=0.05) but not with cognitive function (β=-0.84; p=0.20). In a multiple linear regression model, there were significant effects of prenatal air pollution exposure on MDI (PM10: β=-4.60; p<0.001, NO2: β=-3.12; p<0.001) and PDI (PM10: β=-7.24; p<0.001, NO2: β=-3.01; p<0.001) at 6 months, but no significant association was found at 12 and 24 months of age. CONCLUSIONS: The findings suggest that exposure to air pollution may result in delayed neurodevelopment in early childhood.
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