Literature DB >> 24631190

Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.

Michał Antoszczak1, Ewa Maj2, Joanna Stefańska3, Joanna Wietrzyk2, Jan Janczak4, Bogumil Brzezinski1, Adam Huczyński5.   

Abstract

A series of 11 novel amides of salinomycin were synthesized for the first time. All the obtained compounds were found to show potent antiproliferative activity against human cancer cell lines including the drug-resistant cancer cells. Four new salinomycin derivatives revealed good antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus epidermidis (MRSE).
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Amides; Antibacterial activity; Anticancer properties; Natural compounds; Polyether ionophores

Mesh：

Substances：

Year:  2014        PMID： 24631190     DOI： 10.1016/j.bmcl.2014.02.042

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Salinomycin Hydroxamic Acids: Synthesis, Structure, and Biological Activity of Polyether Ionophore Hybrids.

Authors:  Björn Borgström; Xiaoli Huang; Eduard Chygorin; Stina Oredsson; Daniel Strand
Journal:  ACS Med Chem Lett       Date:  2016-04-25       Impact factor: 4.345

2.  Discovery of a (19)F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells.

Authors:  Qiuyan Shi; Yu Li; Shaowei Bo; Xiaofei Li; Peng Zhao; Qi Liu; Zhigang Yang; Hengjiang Cong; Hexiang Deng; Mingnan Chen; Shizhen Chen; Xin Zhou; Hong Ding; Zhong-Xing Jiang
Journal:  Chem Commun (Camb)       Date:  2016-03-21       Impact factor: 6.222

3.  Overcoming Resistance to Platinum-Based Drugs in Ovarian Cancer by Salinomycin and Its Derivatives-An In Vitro Study.

Authors:  Marcin Michalak; Michał Stefan Lach; Michał Antoszczak; Adam Huczyński; Wiktoria Maria Suchorska
Journal:  Molecules       Date:  2020-01-26       Impact factor: 4.411

4.  Synthesis and Anticancer Activity of Dimeric Polyether Ionophores.

Authors:  Michał Sulik; Ewa Maj; Joanna Wietrzyk; Adam Huczyński; Michał Antoszczak
Journal:  Biomolecules       Date:  2020-07-12

5.  Synthesis of Functionalized N-(4-Bromophenyl)furan-2-carboxamides via Suzuki-Miyaura Cross-Coupling: Anti-Bacterial Activities against Clinically Isolated Drug Resistant A. baumannii, K. pneumoniae, E. cloacae and MRSA and Its Validation via a Computational Approach.

Authors:  Ayesha Siddiqa; Muhammad Zubair; Muhammad Bilal; Nasir Rasool; Muhammad Usman Qamar; Aqsa Khalid; Gulraiz Ahmad; Muhammad Imran; Sajid Mahmood; Ghulam Abbas Ashraf
Journal:  Pharmaceuticals (Basel)       Date:  2022-07-08

Review 6.  Salinomycin as a potent anticancer stem cell agent: State of the art and future directions.

Authors:  Dan Qi; Yunyi Liu; Juan Li; Jason H Huang; Xiaoxiao Hu; Erxi Wu
Journal:  Med Res Rev       Date:  2021-11-16       Impact factor: 12.388

7.  Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models.

Authors:  Alicja Urbaniak; Megan R Reed; Daniel Fil; Anika Moorjani; Sarah Heflin; Michał Antoszczak; Michał Sulik; Adam Huczyński; Michalina Kupsik; Robert L Eoff; Melanie C MacNicol; Timothy C Chambers; Angus M MacNicol
Journal:  Biomed Pharmacother       Date:  2021-06-12       Impact factor: 7.419

8.  In vitro activity of salinomycin and monensin derivatives against Trypanosoma brucei.

Authors:  Dietmar Steverding; Michał Antoszczak; Adam Huczyński
Journal:  Parasit Vectors       Date:  2016-07-25       Impact factor: 3.876

9.  Boromycin Kills Mycobacterial Persisters without Detectable Resistance.

Authors:  Wilfried Moreira; Dinah B Aziz; Thomas Dick
Journal:  Front Microbiol       Date:  2016-02-22       Impact factor: 5.640
  9 in total

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