Sonya S Lowe1, Brita Danielson2, Crystal Beaumont3, Sharon M Watanabe4, Vickie E Baracos4, Kerry S Courneya5. 1. Department of Symptom Control and Palliative Care, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address: Sonya.Lowe@albertahealthservices.ca. 2. Division of Radiation Oncology, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada. 3. Department of Symptom Control and Palliative Care, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada. 4. Division of Palliative Care Medicine, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada. 5. Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada.
Abstract
CONTEXT: Physical activity has demonstrated benefits for quality of life (QoL) and cancer-related fatigue earlier in the cancer trajectory; however, less is known regarding its role in patients with end-stage cancer. OBJECTIVES: The primary aim of this study was to examine the association between objectively measured physical activity and QoL in cancer patients with brain metastases. METHODS: Patients diagnosed with brain metastases, aged 18 years or older, cognitively intact, and with Palliative Performance Scale scores greater than 30%, were recruited from a multidisciplinary brain metastases clinic. A cross-sectional survey interview assessed self-reported QoL (McGill Quality of Life Questionnaire), self-reported physical function (Late-Life Function and Disability Instrument), and symptoms (Edmonton Symptom Assessment System). Participants wore activPAL™ (PAL Technologies, Ltd., Glasgow, UK) accelerometers recording triaxial movement for seven days during palliative whole brain radiotherapy. RESULTS: A total of 31 patients were recruited. Median survival was 171 days from time of study consent, with 90% (28 of 31) of deaths by two year follow-up. Participants who stood for 1.6 hours or more per day had better QoL (mean=1.0; 95% confidence interval [CI]=0.1 to 1.9; P=0.034). Participants who stood for 1.6 hours or more per day had better QoL (mean=1.0; 95% CI=0.1 to 1.9; P=0.034). Participants who sat or were supine for 20.7 hours or more per day had better advanced lower extremity functioning (mean=-6.1; 95% CI=-11.9 to -0.3; P=0.040) and total functioning (mean=-10.6; 95% CI=-21.1 to -0.04; P=0.049), but worse depression (mean=2.1; 95% CI=0.3 to 3.9; P=0.028), anxiety (mean=2.8; 95% CI=0.7 to 5.0; P=0.012), and feeling of well-being (mean=1.9; 95% CI=0.2 to 3.6; P=0.028). CONCLUSION: Sedentary behavior appears to be associated with better physical functioning but worse psychosocial functioning in cancer patients with brain metastases.
CONTEXT: Physical activity has demonstrated benefits for quality of life (QoL) and cancer-related fatigue earlier in the cancer trajectory; however, less is known regarding its role in patients with end-stage cancer. OBJECTIVES: The primary aim of this study was to examine the association between objectively measured physical activity and QoL in cancerpatients with brain metastases. METHODS:Patients diagnosed with brain metastases, aged 18 years or older, cognitively intact, and with Palliative Performance Scale scores greater than 30%, were recruited from a multidisciplinary brain metastases clinic. A cross-sectional survey interview assessed self-reported QoL (McGill Quality of Life Questionnaire), self-reported physical function (Late-Life Function and Disability Instrument), and symptoms (Edmonton Symptom Assessment System). Participants wore activPAL™ (PAL Technologies, Ltd., Glasgow, UK) accelerometers recording triaxial movement for seven days during palliative whole brain radiotherapy. RESULTS: A total of 31 patients were recruited. Median survival was 171 days from time of study consent, with 90% (28 of 31) of deaths by two year follow-up. Participants who stood for 1.6 hours or more per day had better QoL (mean=1.0; 95% confidence interval [CI]=0.1 to 1.9; P=0.034). Participants who stood for 1.6 hours or more per day had better QoL (mean=1.0; 95% CI=0.1 to 1.9; P=0.034). Participants who sat or were supine for 20.7 hours or more per day had better advanced lower extremity functioning (mean=-6.1; 95% CI=-11.9 to -0.3; P=0.040) and total functioning (mean=-10.6; 95% CI=-21.1 to -0.04; P=0.049), but worse depression (mean=2.1; 95% CI=0.3 to 3.9; P=0.028), anxiety (mean=2.8; 95% CI=0.7 to 5.0; P=0.012), and feeling of well-being (mean=1.9; 95% CI=0.2 to 3.6; P=0.028). CONCLUSION: Sedentary behavior appears to be associated with better physical functioning but worse psychosocial functioning in cancerpatients with brain metastases.
Authors: Emily Jeffery; Yc Gary Lee; Joanne McVeigh; Leon Straker; Troy Wooding; Robert U Newton; Carolyn Peddle-McIntyre Journal: Support Care Cancer Date: 2017-04-28 Impact factor: 3.603
Authors: Sriram Yennurajalingam; Supakarn Tayjasanant; Dave Balachandran; Nikhil S Padhye; Janet L Williams; Diane D Liu; Susan Frisbee-Hume; Eduardo Bruera Journal: J Palliat Med Date: 2016-05-05 Impact factor: 2.947
Authors: Cecilie Holländer-Mieritz; Ivan R Vogelius; Claus A Kristensen; Allan Green; Judith L Rindum; Helle Pappot Journal: JMIR Res Protoc Date: 2021-05-13