| Literature DB >> 24630717 |
Malte Schmick1, Philippe I H Bastiaens2.
Abstract
Cellular membranes are constantly reshaped by vesicular fission and fusion as well as by interactions with the dynamic cytoskeleton. Signaling activity at membranes depends on their geometric parameters, such as surface area and curvature; these affect local concentration and thereby regulate the potency of molecular reactions. A membrane's shape is thus inextricably tied to information processing. Here, we review how a trinity of signaling, cytoskeletal dynamics, and membrane shape interact within a closed-loop causality that gives rise to an energy-consuming, self-organized system that changes shape to sense the extracellular environment.Mesh：
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Year: 2014 PMID： 24630717 DOI： 10.1016/j.cell.2014.02.007
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582