| Literature DB >> 24630716 |
Siyuan Zheng1, Hoon Kim1, Roel G W Verhaak2.
Abstract
Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.Entities:
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Year: 2014 PMID： 24630716 DOI： 10.1016/j.cell.2014.02.037
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582