| Literature DB >> 24630562 |
Scott D Kuduk1, Jason W Skudlarek2, Christina N Di Marco2, Joseph G Bruno3, Mark A Pausch3, Julie A O'Brien3, Tamara D Cabalu4, Joanne Stevens5, Joseph Brunner5, Pamela L Tannenbaum5, Anthony L Gotter6, Christopher J Winrow6, John J Renger6, Paul J Coleman2.
Abstract
Analogs of the dual orexin receptor antagonist filorexant were prepared. Replacement of the ether linkage proved highly sensitive toward modification with an acetylene linkage providing compounds with the best in vitro and in vivo potency profiles.Entities:
Keywords: Antagonist; Insomnia; Orexin
Mesh：
Substances：
Year: 2014 PMID： 24630562 DOI： 10.1016/j.bmcl.2014.02.026
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823