Alexander Sidelmann Christensen1, Jonas Bech Møller2, Hans Carl Hasselbalch3. 1. Department of Hematology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark. Electronic address: axchristensen@gmail.com. 2. Quantitative Clinical Pharmacology, Novo Nordisk A/S, Søborg, Denmark. 3. Department of Hematology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark.
Abstract
BACKGROUND: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality. METHODS: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years. RESULTS: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts. CONCLUSION: Kidney impairment might contribute to the increased mortality observed in MPN patients.
BACKGROUND: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality. METHODS: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years. RESULTS: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts. CONCLUSION:Kidney impairment might contribute to the increased mortality observed in MPN patients.
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