Jia-Sheng Rao1, Manxiu Ma2, Can Zhao1, Ai-Feng Zhang3, Zhao-Yang Yang4, Zuxiang Liu2, Xiao-Guang Li5. 1. Department of Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China. 2. State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. 3. Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100068, China. 4. Department of Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China; Institutes for Neuroscience, Capital Medical University, Beijing 100069, China. 5. Department of Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China; Institutes for Neuroscience, Capital Medical University, Beijing 100069, China. Electronic address: lxgchina@sina.com.
Abstract
PURPOSE: Although functional magnetic resonance imaging (fMRI) has revealed that spinal cord injury (SCI) causes anomalous changes in task-induced brain activation, its effect during the resting state remains unclear. The aim of this study is to explore the changes of the brain resting-state function in non-human primates with unilateral SCI. MATERIALS AND METHODS: Eleven adult female rhesus monkeys were subjected to resting-state fMRI: five with unilateral thoracic SCI and six healthy monkeys, to obtain the fractional amplitude of low-frequency fluctuations (fALFF) of the blood oxygenation level-dependent (BOLD) contrast signal to determine the influence of SCI on the cerebral resting-state function. RESULTS: The SCI-induced fALFF vary significantly in several encephalic regions, including the left cerebellum, the left thalamus, the right lateral geniculate nucleus, the right superior parietal lobule, and the posterior cingulate gyrus. CONCLUSION: Analysis of the resting-state fMRI provides evidence of abnormal spontaneous brain activations in primates with SCI, which may help us understand the pathophysiologic mechanisms underlying the changes in neural plasticity in the central nervous system after SCI. Crown
PURPOSE: Although functional magnetic resonance imaging (fMRI) has revealed that spinal cord injury (SCI) causes anomalous changes in task-induced brain activation, its effect during the resting state remains unclear. The aim of this study is to explore the changes of the brain resting-state function in non-human primates with unilateral SCI. MATERIALS AND METHODS: Eleven adult female rhesus monkeys were subjected to resting-state fMRI: five with unilateral thoracic SCI and six healthy monkeys, to obtain the fractional amplitude of low-frequency fluctuations (fALFF) of the blood oxygenation level-dependent (BOLD) contrast signal to determine the influence of SCI on the cerebral resting-state function. RESULTS: The SCI-induced fALFF vary significantly in several encephalic regions, including the left cerebellum, the left thalamus, the right lateral geniculate nucleus, the right superior parietal lobule, and the posterior cingulate gyrus. CONCLUSION: Analysis of the resting-state fMRI provides evidence of abnormal spontaneous brain activations in primates with SCI, which may help us understand the pathophysiologic mechanisms underlying the changes in neural plasticity in the central nervous system after SCI. Crown
Authors: Akinwunmi Oni-Orisan; Mayank Kaushal; Wenjun Li; Jack Leschke; B Douglas Ward; Aditya Vedantam; Benjamin Kalinosky; Matthew D Budde; Brian D Schmit; Shi-Jiang Li; Vaishnavi Muqeet; Shekar N Kurpad Journal: PLoS One Date: 2016-03-08 Impact factor: 3.240