Literature DB >> 24629394

Hemangioblastomas in the elderly: epidemiology and clinical characteristics.

Charles D Kassardjian1, R Loch Macdonald2, David G Munoz3.   

Abstract

Intracranial hemangioblastomas are benign vascular tumors. The peak age of incidence is between 20 to 50 years. Hemangioblastomas rarely occur in patients over the age of 65. To our knowledge there is no review of the prevalence and clinical features in an elderly population. We reviewed our 12 year experience with intracranial hemangioblastomas, and characterized the clinical features of hemangioblastomas in patients over the age of 65. We present a 72-year-old man with a cerebellar mass initially thought to be a metastasis as an illustrative case. We reviewed our pathology database and identified all patients with a histopathologically confirmed diagnosis of hemangioblastoma over the last 12 years in a large tertiary adult hospital; all patients were over the age of 18. Of all cases of hemangioblastoma in the last 12 years, six of 77 (7.7%) occurred in patients over the age of 65. All were cerebellar in location, and none were associated with von-Hippel Lindau disease. Hemangioblastomas are uncommon, but not rare, in patients over the age of 65, and should be included in the differential diagnosis of patients presenting with gait ataxia and a cerebellar lesion in this age group.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cerebellar tumor; Elderly; Hemangioblastoma; von-Hippel Lindau

Mesh:

Year:  2013        PMID: 24629394     DOI: 10.1016/j.jocn.2013.10.023

Source DB:  PubMed          Journal:  J Clin Neurosci        ISSN: 0967-5868            Impact factor:   1.961


  5 in total

1.  Sporadic Hemangioblastoma Arising from the Infundibulum.

Authors:  Michael N Pakdaman; Matthew J Austin; Serguei Bannykh; Barry D Pressman
Journal:  J Radiol Case Rep       Date:  2017-05-31

Review 2.  The Role of Propranolol as a Repurposed Drug in Rare Vascular Diseases.

Authors:  Angel M Cuesta; Eunate Gallardo-Vara; Juan Casado-Vela; Lucía Recio-Poveda; Luisa-María Botella; Virginia Albiñana
Journal:  Int J Mol Sci       Date:  2022-04-11       Impact factor: 6.208

3.  Propranolol reduces viability and induces apoptosis in hemangioblastoma cells from von Hippel-Lindau patients.

Authors:  Virginia Albiñana; Karina Villar Gómez de Las Heras; Gemma Serrano-Heras; Tomás Segura; Ana Belén Perona-Moratalla; Mercedes Mota-Pérez; José María de Campos; Luisa María Botella
Journal:  Orphanet J Rare Dis       Date:  2015-09-22       Impact factor: 4.123

4.  The β2-adrenergic receptor antagonist ICI-118,551 blocks the constitutively activated HIF signalling in hemangioblastomas from von Hippel-Lindau disease.

Authors:  A M Cuesta; V Albiñana; E Gallardo-Vara; L Recio-Poveda; I de Rojas-P; K Villar Gómez de Las Heras; D T Aguirre; L M Botella
Journal:  Sci Rep       Date:  2019-07-11       Impact factor: 4.379

5.  Blockade of β2-Adrenergic Receptor Reduces Inflammation and Oxidative Stress in Clear Cell Renal Cell Carcinoma.

Authors:  Virginia Albiñana; Lucía Recio-Poveda; Pilar González-Peramato; Luis Martinez-Piñeiro; Luisa María Botella; Angel M Cuesta
Journal:  Int J Mol Sci       Date:  2022-01-25       Impact factor: 5.923

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.