| Literature DB >> 24628626 |
Kenichiro Kobayashi1, Kazumasa Mitsui, Hitoshi Ichikawa, Kazuhiko Nakabayashi, Masaki Matsuoka, Yasuko Kojima, Hiroyuki Takahashi, Kazutoshi Iijima, Kaori Ootsubo, Keisuke Oboki, Hajime Okita, Kazuki Yasuda, Hiromi Sakamoto, Kenichiro Hata, Teruhiko Yoshida, Kenji Matsumoto, Nobutaka Kiyokawa, Akira Ohara.
Abstract
We identified ATF7IP as a novel PDGFRB fusion partner in B-progenitor acute lymphoblastic leukaemia (B-ALL) and showed that B-ALL with ATF7IP/PDGFRB translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)-like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B-ALL cases with high PDGFRB expression level in the context of the Ph-like ALL gene are likely to have a PDGFRB translocation. Thus, it is possible that measurement of the PDGFRB expression level can be utilized as a screening test for the detection of the cryptic PDGFRB translocation, especially within the Ph-like ALL subgroup.Entities:
Keywords: ATF7IP; PDGFRB; Ph-like; acute lymphoblastic leukaemia; screening
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Year: 2014 PMID： 24628626 DOI： 10.1111/bjh.12834
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998