BACKGROUND: Pneumococcal diseases play a major role in human morbidity and mortality. We present the results of a Danish nationwide study of recurrent paediatric invasive pneumococcal disease (rIPD) focusing on the epidemiological, microbiological, and clinical aspects. METHODS: All laboratory-confirmed cases of IPD in children aged 0-15 y were identified from the Neisseria and Streptococcus Reference Laboratory, Statens Serum Institut, Denmark for the period 1980-2013. rIPD was defined as isolation of Streptococcus pneumoniae from any normally sterile site ≥ 30 days after an initial positive culture. Clinical data were obtained for all children with rIPD. RESULTS: Of all children with IPD, 2.4% (59/2418) experienced at least 1 episode of rIPD, and an underlying condition was documented in 39 (66%). Immune deficiency due to transplantation (n = 9) was the most common disease; however, anatomic abnormalities (n = 8), complement C2 deficiency (n = 4), and congenital asplenia (n = 3) were all registered more than once. No underlying disease was detected in 18 children (31%). Based on the serotype distribution of S. pneumoniae isolates in rIPD among children aged 0-5 y (n = 41), 51%, 66%, and 78% of the cases would have been covered by the 7-, 10-, and 13-valent pneumococcal conjugate vaccines, respectively. CONCLUSIONS: Of children with an IPD episode, 2.4% experienced rIPD, and an underlying disease was documented in 66% of these children. Investigation of underlying conditions is essential in episodes of rIPD.
BACKGROUND:Pneumococcal diseases play a major role in human morbidity and mortality. We present the results of a Danish nationwide study of recurrent paediatric invasive pneumococcal disease (rIPD) focusing on the epidemiological, microbiological, and clinical aspects. METHODS: All laboratory-confirmed cases of IPD in children aged 0-15 y were identified from the Neisseria and Streptococcus Reference Laboratory, Statens Serum Institut, Denmark for the period 1980-2013. rIPD was defined as isolation of Streptococcus pneumoniae from any normally sterile site ≥ 30 days after an initial positive culture. Clinical data were obtained for all children with rIPD. RESULTS: Of all children with IPD, 2.4% (59/2418) experienced at least 1 episode of rIPD, and an underlying condition was documented in 39 (66%). Immune deficiency due to transplantation (n = 9) was the most common disease; however, anatomic abnormalities (n = 8), complement C2 deficiency (n = 4), and congenital asplenia (n = 3) were all registered more than once. No underlying disease was detected in 18 children (31%). Based on the serotype distribution of S. pneumoniae isolates in rIPD among children aged 0-5 y (n = 41), 51%, 66%, and 78% of the cases would have been covered by the 7-, 10-, and 13-valent pneumococcal conjugate vaccines, respectively. CONCLUSIONS: Of children with an IPD episode, 2.4% experienced rIPD, and an underlying disease was documented in 66% of these children. Investigation of underlying conditions is essential in episodes of rIPD.
Authors: Helene Ingels; Lone Schejbel; A C Lundstedt; Lise Jensen; Inga A Laursen; Lars P Ryder; Niels H H Heegaard; Helle Konradsen; Jens Jørgen Christensen; Carsten Heilmann; Hanne V Marquart Journal: Pediatr Infect Dis J Date: 2015-06 Impact factor: 2.129
Authors: Laia Alsina; Maria G Basteiro; Hector D de Paz; Melania Iñigo; Mariona F de Sevilla; Miriam Triviño; Manel Juan; Carmen Muñoz-Almagro Journal: PLoS One Date: 2015-03-04 Impact factor: 3.240
Authors: Yousif Murad; Te-Yu Hung; Manish Sadarangani; Shaun K Morris; Nicole Le Saux; Otto G Vanderkooi; James D Kellner; Gregory J Tyrrell; Irene Martin; Walter Demczuk; Scott A Halperin; Julie A Bettinger; N Bridger; Cheryl Foo; S A Halperin; K A Top; R Thibeault; D Moore; J Papenburg; M Lebel; N Le Saux; S Morris; J Embree; B Tan; Athena McConnell; T Jadavji; C Constantinescu; W Vaudry; D Scheifele; M Sadarangani; J Bettinger; L Sauvé Journal: Pediatr Infect Dis J Date: 2022-04-01 Impact factor: 3.806