CONCLUSION: High-risk human papillomavirus (HPV) infection was significantly related to lymph node size in patients with single node metastasis of oral and oropharyngeal cancer. OBJECTIVE: The purpose of this study was to examine the relationship between high-risk HPV infection and lymph node size in patients with single node metastasis of oral and oropharyngeal carcinoma. METHODS: This study included 48 patients with oral and oropharyngeal carcinoma. Pathologic lymph node stages comprised 36 N1 and 12 N2a. RESULTS: High-risk HPV in situ hybridization was positive in 29% of patients (14/48). Of those patients with high-risk HPV, there was a significant difference (p = 0.008) between oral (9.5%) and oropharyngeal (44.4%) cancers. Average lymph node diameter was 20.7 ± 12.6 mm (range 5-54 mm). We found a positive correlation between high-risk HPV status and lymph node size (p = 0.018). Mean lymph node diameter in high-risk HPV-positive cases was 27.3 ± 13.1 mm and 18.0 ± 11.5 mm in high-risk HPV-negative cases. Extracapsular spread (p = 0.030) and cystic nodal metastases (p = 0.019) were also significantly related to lymph node size. High-risk HPV negative status (p = 0.043), advanced tumor stage (p = 0.009), and extracapsular spread (p = 0.038) all had significant adverse effects on 5-year disease-specific survival.
CONCLUSION: High-risk human papillomavirus (HPV) infection was significantly related to lymph node size in patients with single node metastasis of oral and oropharyngeal cancer. OBJECTIVE: The purpose of this study was to examine the relationship between high-risk HPV infection and lymph node size in patients with single node metastasis of oral and oropharyngeal carcinoma. METHODS: This study included 48 patients with oral and oropharyngeal carcinoma. Pathologic lymph node stages comprised 36 N1 and 12 N2a. RESULTS: High-risk HPV in situ hybridization was positive in 29% of patients (14/48). Of those patients with high-risk HPV, there was a significant difference (p = 0.008) between oral (9.5%) and oropharyngeal (44.4%) cancers. Average lymph node diameter was 20.7 ± 12.6 mm (range 5-54 mm). We found a positive correlation between high-risk HPV status and lymph node size (p = 0.018). Mean lymph node diameter in high-risk HPV-positive cases was 27.3 ± 13.1 mm and 18.0 ± 11.5 mm in high-risk HPV-negative cases. Extracapsular spread (p = 0.030) and cystic nodal metastases (p = 0.019) were also significantly related to lymph node size. High-risk HPV negative status (p = 0.043), advanced tumor stage (p = 0.009), and extracapsular spread (p = 0.038) all had significant adverse effects on 5-year disease-specific survival.
Authors: T J Rath; S Narayanan; M A Hughes; R L Ferris; S I Chiosea; B F Branstetter Journal: AJNR Am J Neuroradiol Date: 2017-04-27 Impact factor: 3.825
Authors: Mi Joo Chung; Yeon Sil Kim; Ji Yoon Kim; Yun Hee Lee; Ji Hyun Jang; Jin Hyoung Kang; Ie Ryung Yoo; Youn Soo Lee Journal: Cancer Res Treat Date: 2016-03-03 Impact factor: 4.679
Authors: Roman O Kowalchuk; Kathryn M Van Abel; Adam B Sauer; Linda X Yin; Joaquin J Garcia; William S Harmsen; Eric J Moore; Daniel L Price; Ashish V Chintakuntlawar; Katharine R Price; Scott C Lester; Michelle Neben Wittich; Samir H Patel; Robert L Foote; Daniel M Ma; Alex A Nagelschneider; David M Routman Journal: Adv Radiat Oncol Date: 2022-02-23