Literature DB >> 24628065

PAS-positive extracellular deposits within germinal centers of hyperplastic follicles during SIV infection in a rhesus macaque.

Jung Joo Hong1, Francois Villinger, Cynthia L Courtney.   

Abstract

BACKGROUND: Lymphoid tissue remodeling is characteristic of chronic simian immunodeficiency virus infection.
METHODS: A rhesus macaque infected with SIVmac239 was necropsied and its lymphoid tissues subjected to histopathology characterization.
RESULTS: Germinal centers in spleen and lymph nodes contained PAS-positive, non-amyloid extracellular deposits, decreased T follicular helper cells, and normal density of Ki67(+) B cells.
CONCLUSIONS: A possible mechanism for PAS-positive deposits includes exaggerated involution of SIV-induced follicular hyperplasia secondary to virus-associated immune reaction.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  Macaca mulatta; T follicular helper cells; lymph node; non-amyloid; spleen

Mesh:

Year:  2014        PMID: 24628065      PMCID: PMC4399816          DOI: 10.1111/jmp.12109

Source DB:  PubMed          Journal:  J Med Primatol        ISSN: 0047-2565            Impact factor:   0.667


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