Literature DB >> 24627550

BuMPing iron with modified heparins.

Jodie L Babitt1, Herbert Y Lin.   

Abstract

In this issue of Blood, Poli et al demonstrate that heparin analogs engineered to minimize their anticoagulant properties can potently downregulate hepcidin production in vitro and in vivo, and may potentially be used to treat the anemia of inflammation.

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Year:  2014        PMID： 24627550      PMCID： PMC3945857          DOI： 10.1182/blood-2014-01-549519

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  10 in total

Review 1.  Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation.

Authors:  Chia Chi Sun; Valentina Vaja; Jodie L Babitt; Herbert Y Lin
Journal:  Am J Hematol       Date:  2012-01-31       Impact factor: 10.047

2.  Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo.

Authors:  Maura Poli; Domenico Girelli; Natascia Campostrini; Federica Maccarinelli; Dario Finazzi; Sara Luscieti; Antonella Nai; Paolo Arosio
Journal:  Blood       Date:  2010-11-12       Impact factor: 22.113

3.  Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo.

Authors:  Maura Poli; Michela Asperti; Annamaria Naggi; Natascia Campostrini; Domenico Girelli; Michela Corbella; Marina Benzi; Celine Besson-Fournier; Helene Coppin; Federica Maccarinelli; Dario Finazzi; Paolo Arosio
Journal:  Blood       Date:  2014-01-07       Impact factor: 22.113

4.  Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.

Authors:  Jodie L Babitt; Franklin W Huang; Diedra M Wrighting; Yin Xia; Yisrael Sidis; Tarek A Samad; Jason A Campagna; Raymond T Chung; Alan L Schneyer; Clifford J Woolf; Nancy C Andrews; Herbert Y Lin
Journal:  Nat Genet       Date:  2006-04-09       Impact factor: 38.330

Review 5.  Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer.

Authors:  Benito Casu; Annamaria Naggi; Giangiacomo Torri
Journal:  Matrix Biol       Date:  2010-04-21       Impact factor: 11.583

6.  The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys.

Authors:  Frank Schwoebel; Lucas T van Eijk; Dirk Zboralski; Simone Sell; Klaus Buchner; Christian Maasch; Werner G Purschke; Martin Humphrey; Stefan Zöllner; Dirk Eulberg; Frank Morich; Peter Pickkers; Sven Klussmann
Journal:  Blood       Date:  2013-01-24       Impact factor: 22.113

Review 7.  Systemic iron homeostasis.

Authors:  Tomas Ganz
Journal:  Physiol Rev       Date:  2013-10       Impact factor: 37.312

8.  A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates.

Authors:  Keegan S Cooke; Beth Hinkle; Hossein Salimi-Moosavi; Ian Foltz; Chadwick King; Palaniswami Rathanaswami; Aaron Winters; Shirley Steavenson; C Glenn Begley; Graham Molineux; Barbra J Sasu
Journal:  Blood       Date:  2013-08-14       Impact factor: 22.113

9.  BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism.

Authors:  Billy Andriopoulos; Elena Corradini; Yin Xia; Sarah A Faasse; Shanzhuo Chen; Lovorka Grgurevic; Mitchell D Knutson; Antonello Pietrangelo; Slobodan Vukicevic; Herbert Y Lin; Jodie L Babitt
Journal:  Nat Genet       Date:  2009-03-01       Impact factor: 38.330

10.  Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance.

Authors:  Jodie L Babitt; Franklin W Huang; Yin Xia; Yisrael Sidis; Nancy C Andrews; Herbert Y Lin
Journal:  J Clin Invest       Date:  2007-07       Impact factor: 14.808
  10 in total

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