Emil Hagström1, Karl Michaëlsson2, Håkan Melhus2, Thomas Hansen2, Håkan Ahlström2, Lars Johansson2, Erik Ingelsson2, Johan Sundström2, Lars Lind2, Johan Arnlöv2. 1. From the Uppsala Clinical Research Center (E.H., E.I., J.S., J.Ä.), Departments of Radiology (T.H., H.A., L.J.) and Medical Sciences (E.H., J.Ä., E.I., J.S., L.L.), Uppsala University, Uppsala, Sweden; and the School of Health and Social Studies, Dalarna University, Falun, Sweden (J.Ä.). emil.hagstrom@ucr.uu.se. 2. From the Uppsala Clinical Research Center (E.H., E.I., J.S., J.Ä.), Departments of Radiology (T.H., H.A., L.J.) and Medical Sciences (E.H., J.Ä., E.I., J.S., L.L.), Uppsala University, Uppsala, Sweden; and the School of Health and Social Studies, Dalarna University, Falun, Sweden (J.Ä.).
Abstract
OBJECTIVE: Cardiovascular risk factors have different impact on different arterial territories. Diseases with elevated circulating parathyroid hormone (PTH) such as primary hyperparathyroidism and chronic renal failure have been shown to be associated with an increased risk of cardiovascular disease, predominantly heart or cerebrovascular diseases. However, data on the associations between circulating PTH and peripheral atherosclerosis are limited. APPROACH AND RESULTS: Two prospective, community-based studies were used. In 306 men and women, who were 70 years old, from the Prospective investigation of the vasculature in Uppsala seniors (PIVUS) study, cross-sectional relations between PTH and atherosclerotic burden assessed by whole-body magnetic resonance angiography were investigated. In 998 men, who were 71 years old, from the Uppsala longitudinal study of adult men (ULSAM) study, the association between PTH concentration and risk of subsequent nonfatal atherosclerotic disease (excluding coronary or cerebrovascular disease) was investigated. Adjusting for established vascular risk factors, PTH was associated with burden of atherosclerosis (increase in total atherosclerotic score per SD PTH increase: 0.04, 0.003-0.08; P=0.03) in the PIVUS study. During follow-up in the ULSAM study (median 16.7 years), 89 men were diagnosed with nonfatal atherosclerotic disease. In Cox-regression analyses adjusting for established vascular risk factors and mineral metabolism, higher PTH was associated with an increased risk of nonfatal atherosclerotic disease (hazard ratio for 1 SD increase of PTH: 1.55, 1.33-1.88; P<0.0001). Results were similar when including fatal atherosclerotic disease in the outcome. CONCLUSIONS: In 2 independent community-based cohorts, PTH was associated to the degree of atherosclerosis and risk of clinically overt atherosclerotic disease, respectively. Our data confirm and extend previous studies supporting a role for PTH in the development of atherosclerotic disease.
OBJECTIVE: Cardiovascular risk factors have different impact on different arterial territories. Diseases with elevated circulating parathyroid hormone (PTH) such as primary hyperparathyroidism and chronic renal failure have been shown to be associated with an increased risk of cardiovascular disease, predominantly heart or cerebrovascular diseases. However, data on the associations between circulating PTH and peripheral atherosclerosis are limited. APPROACH AND RESULTS: Two prospective, community-based studies were used. In 306 men and women, who were 70 years old, from the Prospective investigation of the vasculature in Uppsala seniors (PIVUS) study, cross-sectional relations between PTH and atherosclerotic burden assessed by whole-body magnetic resonance angiography were investigated. In 998 men, who were 71 years old, from the Uppsala longitudinal study of adult men (ULSAM) study, the association between PTH concentration and risk of subsequent nonfatal atherosclerotic disease (excluding coronary or cerebrovascular disease) was investigated. Adjusting for established vascular risk factors, PTH was associated with burden of atherosclerosis (increase in total atherosclerotic score per SD PTH increase: 0.04, 0.003-0.08; P=0.03) in the PIVUS study. During follow-up in the ULSAM study (median 16.7 years), 89 men were diagnosed with nonfatal atherosclerotic disease. In Cox-regression analyses adjusting for established vascular risk factors and mineral metabolism, higher PTH was associated with an increased risk of nonfatal atherosclerotic disease (hazard ratio for 1 SD increase of PTH: 1.55, 1.33-1.88; P<0.0001). Results were similar when including fatal atherosclerotic disease in the outcome. CONCLUSIONS: In 2 independent community-based cohorts, PTH was associated to the degree of atherosclerosis and risk of clinically overt atherosclerotic disease, respectively. Our data confirm and extend previous studies supporting a role for PTH in the development of atherosclerotic disease.
Authors: Nicolas D Verheyen; Katharina Kienreich; Martin Gaksch; Adriana J van Ballegooijen; Martin R Grübler; Briain Ó Hartaigh; Johannes Schmid; Astrid Fahrleitner-Pammer; Elisabeth Kraigher-Krainer; Caterina Colantonio; Evgeny Belyavskiy; Gerlies Treiber; Cristiana Catena; Helmut Brussee; Burkert Pieske; Winfried März; Andreas Tomaschitz; Stefan Pilz Journal: J Clin Hypertens (Greenwich) Date: 2015-10-12 Impact factor: 3.738