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Literature DB >> 2462617

Low lumbar CSF levels of homovanillic acid and 5-hydroxyindoleacetic acid in multiple system atrophy with autonomic failure.

R J Polinsky¹, R T Brown, R S Burns, J Harvey-White, I J Kopin.

Abstract

Low lumbar CSF concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in patients with multiple system atrophy attended by autonomic failure (MSA) reflect decreased activity in central dopaminergic and serotonergic pathways. These neurochemical changes are consistent with the neuropathological involvement in MSA and distinguish such patients from those with pure autonomic failure who have normal CSF metabolite levels.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 1988 PMID： 2462617 PMCID： PMC1033193 DOI： 10.1136/jnnp.51.7.914

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

19 in total

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6 in total

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2. Low lumbar CSF concentrations of homovanillic acid in the autosomal dominant ataxias.

Authors: J J Higgins; J D Harvey-White; I J Kopin
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