Eva Kitzlerová1, Zdenĕk Fisar1, Roman Jirák1, Martina Zvĕrová1, Jana Hroudová1, Hana Benaková2, Jirí Raboch1. 1. Department of Psychiatry, 1st Faculty of Medicine, Charles University Prague and General Teaching Hospital, Czech Republic. 2. Institute of Medical Biochemistry and Laboratory Diagnostics, Charles University in Prague and General University Hospital in Prague, Czech Republic.
Abstract
OBJECTIVE: Elevated homocysteine is associated with a variety of diseases, including Alzheimer's disease (AD) and depressive disorder. This study was designed to detect an association between plasma homocysteine and AD with or without co-morbid depressive symptoms. METHODS: Plasma homocysteine concentrations were measured in 85 AD patients (36 of them with depressive symptoms), 33 non-AD patients with a depression diagnosis and 44 healthy controls, all aged above 50 years. RESULTS: Positive correlation between age and homocysteine was confirmed. Significantly higher mean plasma homocysteine was found in AD patients, but not in depressive patients, when compared with controls. We confirmed significant correlation between homocysteine concentration and the degree of cognitive impairment in AD patients. There was no incremental effect of concurrent depressive symptoms on homocysteine concentration in AD patients. CONCLUSION: The association of high homocysteine with degree of cognitive impairment or stage of dementia in AD indicate potential role of high plasma homocysteine as a biomarker of the disease and/or indicator of brain damage during the progression of AD dementia.
OBJECTIVE: Elevated homocysteine is associated with a variety of diseases, including Alzheimer's disease (AD) and depressive disorder. This study was designed to detect an association between plasma homocysteine and AD with or without co-morbid depressive symptoms. METHODS: Plasma homocysteine concentrations were measured in 85 ADpatients (36 of them with depressive symptoms), 33 non-ADpatients with a depression diagnosis and 44 healthy controls, all aged above 50 years. RESULTS: Positive correlation between age and homocysteine was confirmed. Significantly higher mean plasma homocysteine was found in ADpatients, but not in depressivepatients, when compared with controls. We confirmed significant correlation between homocysteine concentration and the degree of cognitive impairment in ADpatients. There was no incremental effect of concurrent depressive symptoms on homocysteine concentration in ADpatients. CONCLUSION: The association of high homocysteine with degree of cognitive impairment or stage of dementia in AD indicate potential role of high plasma homocysteine as a biomarker of the disease and/or indicator of brain damage during the progression of AD dementia.
Authors: Melanie Horita; Carolina Tosin Bueno; Andrea R Horimoto; Pedro A Lemos; Antonio A Morandini-Filho; Jose E Krieger; Paulo C J L Santos; Alexandre C Pereira Journal: Int J Cardiol Heart Vasc Date: 2016-11-24
Authors: Eva Kitzlerová; Zdeněk Fišar; Petra Lelková; Roman Jirák; Martina Zvěřová; Jana Hroudová; Ada Manukyan; Pavel Martásek; Jiří Raboch Journal: Med Sci Monit Date: 2018-04-28