Tian Xu1, Jin Tao Zhang2, Mei Yang3, Huan Zhang1, Wen Qing Liu2, Yan Kong2, Tan Xu1, Yong Hong Zhang1. 1. Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, Jiangsu, China. 2. Department of Neurology, Chinese PLA 88 Hospital, Tai'an 271000, Shandong, China. 3. Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China.
Abstract
OBJECTIVE: To study the relationship between dyslipidemia and outcome in patients with acute ischemic stroke. METHODS: Data about 1 568 patients with acute ischemic stroke were collected from 4 hospitals in Shandong Province from January 2006 to December 2008. National Institute of Health Stroke Scale (NIHSS) >10 at discharge or death was defined as the outcome. Effect of dyslipidemia on outcome in patients with acute ischemic stroke was analyzed by multivariate logistic regression analysis and propensity score-adjusted analysis, respectively. RESULTS: The serum levels of TC, LDL-C, and HDL-C were significantly associated with the outcome in patients with acute ischemic stroke. Multivariate logistic regression analysis and propensity score-adjusted analysis showed that the ORs and 95% CIs were 3.013 (1.259, 7.214)/2.655 (1.298, 5.43), 3.157 (1.306, 7.631)/3.405 (1.621, 7.154), and 0.482 (0.245, 0.946)/0.51 (0.282, 0.921), respectively, for patients with acute ischemic stroke. Hosmer-Lemeshow goodness-of-fit test showed no significant difference in observed and predicted risk in patients with acute ischemic stroke (chi-square=8.235, P=0.411). CONCLUSION: Serum levels of TC, LDL-C, and HDL-C are positively related with the outcome in patients with acute ischemic stroke.
OBJECTIVE: To study the relationship between dyslipidemia and outcome in patients with acute ischemic stroke. METHODS: Data about 1 568 patients with acute ischemic stroke were collected from 4 hospitals in Shandong Province from January 2006 to December 2008. National Institute of Health Stroke Scale (NIHSS) >10 at discharge or death was defined as the outcome. Effect of dyslipidemia on outcome in patients with acute ischemic stroke was analyzed by multivariate logistic regression analysis and propensity score-adjusted analysis, respectively. RESULTS: The serum levels of TC, LDL-C, and HDL-C were significantly associated with the outcome in patients with acute ischemic stroke. Multivariate logistic regression analysis and propensity score-adjusted analysis showed that the ORs and 95% CIs were 3.013 (1.259, 7.214)/2.655 (1.298, 5.43), 3.157 (1.306, 7.631)/3.405 (1.621, 7.154), and 0.482 (0.245, 0.946)/0.51 (0.282, 0.921), respectively, for patients with acute ischemic stroke. Hosmer-Lemeshow goodness-of-fit test showed no significant difference in observed and predicted risk in patients with acute ischemic stroke (chi-square=8.235, P=0.411). CONCLUSION: Serum levels of TC, LDL-C, and HDL-C are positively related with the outcome in patients with acute ischemic stroke.