Literature DB >> 2462503

T cell responses of normal individuals towards recombinant protein antigens of Mycobacterium tuberculosis.

M E Munk1, B Schoel, S H Kaufmann.   

Abstract

Recombinant beta-galactosidase fusion proteins from Mycobacterium tuberculosis were purified by affinity chromatography and used for stimulation of unselected T lymphocytes freshly isolated from healthy individuals. It was found that the 12-kDa, 19-kDa, 65-kDa and 71-kDa recombinant (r) proteins tested stimulated T cells from healthy individuals in an antigen-specific way. These data demonstrate that it is feasible to screen purified r-proteins with unselected T cell populations. The existence of T cells with reactivity to these antigens in healthy individuals suggests T cell activation independent from clinical disease and hence that these proteins are not indicative for active tuberculosis.

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Year:  1988        PMID： 2462503     DOI： 10.1002/eji.1830181128

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  25 in total

1.  Prevention of adjuvant arthritis in rats by a nonapeptide from the 65-kD mycobacterial heat shock protein: specificity and mechanism.

Authors:  X D Yang; J Gasser; U Feige
Journal:  Clin Exp Immunol       Date:  1992-01       Impact factor: 4.330

Review 2.  Heat-shock proteins and pathogenesis of bacterial infections.

Authors:  S H Kaufmann
Journal:  Springer Semin Immunopathol       Date:  1991

3.  Analysis of human T-cell epitopes in the 19,000 MW antigen of Mycobacterium tuberculosis: influence of HLA-DR.

Authors:  A Faith; C Moreno; R Lathigra; E Roman; M Fernandez; S Brett; D M Mitchell; J Ivanyi; A D Rees
Journal:  Immunology       Date:  1991-09       Impact factor: 7.397

Review 4.  Heat shock proteins: friend and foe?

Authors:  M Harboe; A J Quayle
Journal:  Clin Exp Immunol       Date:  1991-10       Impact factor: 4.330

5.  Molecular cloning and sequence analysis of the Sta58 major antigen gene of Rickettsia tsutsugamushi: sequence homology and antigenic comparison of Sta58 to the 60-kilodalton family of stress proteins.

Authors:  C K Stover; D P Marana; G A Dasch; E V Oaks
Journal:  Infect Immun       Date:  1990-05       Impact factor: 3.441

6.  HLA-DR4-restricted T-cell epitopes from the mycobacterial 60,000 MW heat shock protein (hsp 60) do not map to the sequence homology regions with the human hsp 60.

Authors:  A S Mustafa; K E Lundin; R H Meloen; T M Shinnick; A F Coulson; F Oftung
Journal:  Immunology       Date:  1996-03       Impact factor: 7.397

7.  Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway.

Authors:  K Suzue; X Zhou; H N Eisen; R A Young
Journal:  Proc Natl Acad Sci U S A       Date:  1997-11-25       Impact factor: 11.205

8.  Heterogeneity of the repertoire of T cells of tuberculosis patients and healthy contacts to Mycobacterium tuberculosis antigens separated by high-resolution techniques.

Authors:  B Schoel; H Gulle; S H Kaufmann
Journal:  Infect Immun       Date:  1992-04       Impact factor: 3.441

9.  Human T cells recognize mycobacterial heat shock proteins in the context of multiple HLA-DR molecules: studies with healthy subjects vaccinated with Mycobacterium bovis BCG and Mycobacterium leprae.

Authors:  A S Mustafa; K E Lundin; F Oftung
Journal:  Infect Immun       Date:  1993-12       Impact factor: 3.441

10.  Human T-cell responses to secreted antigen fractions of Mycobacterium tuberculosis.

Authors:  H Boesen; B N Jensen; T Wilcke; P Andersen
Journal:  Infect Immun       Date:  1995-04       Impact factor: 3.441
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