| Literature DB >> 2462501 |
T Hirano1, T Matsuda, M Turner, N Miyasaka, G Buchan, B Tang, K Sato, M Shimizu, R Maini, M Feldmann.
Abstract
High levels of interleukin 6 (IL 6/B cell stimulatory factor-2) were detected in synovial fluids from the joints of patients with active rheumatoid arthritis (RA). The cells found in freshly isolated synovial fluid constitutively expressed IL 6 mRNA. The synovial tissues obtained by joint biopsy were also found to produce IL 6 in vitro. Immunohistochemical analysis demonstrated that CD2+ T cells as well as CD20+ blastoid B cells in the synovial tissues produce IL 6. The data indicate that IL 6 is generated constitutively in RA and its overproduction may explain the local as well as the generalized symptoms of RA, since IL 6 can function as B cell growth and differentiation factor as well as hepatocyte-stimulating factor.Entities:
Mesh：
Substances：
Year: 1988 PMID： 2462501 DOI： 10.1002/eji.1830181122
Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532