Glandular odontogenic cyst: review of literature and report of a new case with cytokeratin-19 expression.

The glandular odontogenic cyst (GOC) was a rare jawbone cyst described in 1988 as a distinct entity. This lesion can involve either jaw, and the anterior region of the mandible was the most commonly affected area. Clinical and radiographic findings were not specific, and the diagnosis of GOC can be extremely difficult due to the rarity of this lesion. The cyst presented a wall constituted by fibrous connective tissue and was lined by a non-keratinized stratified squamous epithelium of variable thickness. Large areas of the lining epithelium presented cylinder cells, sometimes ciliated. A variable amount of mucina was occasionally noted. Due to the strong similarities, this cyst can be easily misdiag-nosed as a central mucoepidermoid carcinoma (CMEC). Immunohistochemistry may be an aid in diagnosis; in fact has been demonstrated that there were differences in the expression of cytokeratins (CK) in GOC and CMEC. In this study, we reported a new case of GOC in a 38 year female patient. In addition, we carried out a review of 110 previous cases reported in literature.

INTRODUCTION

The glandular odontogenic cyst (GOC) is an uncommon cyst of the jaws, locally aggressive and with recurring potential [1, 2], which poses a diagnostic and therapeutic challenge. In 1987, Padayachee and Van Wyk [3] described two cystic lesions with histologic features that did not fit into the known classification of cysts, who called “sialo-odontogenic cyst”. One year later Gardner et al. [4] described eight cases with similar histological appearance and suggested the term “glandular odontogenic cyst”. In 1992, the WHO [1] named the GOC an independent pathologic entity and classified it as a developmental odontogenic cyst.

Clinically, the most common site of occurrence is the mandible, especially in the anterior region, presenting as an asymptomatic swelling [5]. This lesion appear as an unilocular or multilocular radiolucency, usually with well-defined margins and in some cases scalloped borders [6]. However, there are no pathognomonic radiological features for GOC [7].

The exact microscopic criteria necessary for diagnosis have not been universally accepted, leading to the consideration that this lesion may not be as rare as it has been considered. In fact, it has been suggested that many cases formerly diagnosed as central mucoepidermoide carcinoma (CMEC) can be cases of GOC and some low-grade CMECs would have originated from GOCs [8]. The reason was that a considerable overlap between histological features of GOC and CMEC was present [9], and some authors suggested the hypothesis that GOC and CMEC of the jaws represent a spectrum of one disease [10]. Thus, several attempts to use molecular markers to facilitate the diagnosis had been made. Some hopeful markers were cytokeratins (CK), mostly CKs 18 and 19, whose expression profile was found different in these two lesions [11].

Due to high recurrence rate and aggressive growth potential [12], some authors believe that marginal resection may be a more reliable treatment for GOC [13]. In the literature, both conservative and radical methods of treatment of GOC have been suggested, but due to the rarity of the condition, treatment recommendations were not evidence based [14, 15]. The prognosis of this cyst still remained unclear, and follow-up should last several years after treatment [16].

In this article, we presented a new case of GOC and conducted a review of literature, taking into consideration 110 previous cases, focusing on epidemiology, clinico-pathologic and radiologic features as well as biologic behavior.

MATERIAL AND METHODOLOGY

In October 2011, a 38-years-old woman was admitted at the University Hospital “Ospedali Riuniti” in Ancona, Italy, with a radiolucent lesion in the anterior mandible. The lesion was asymptomatic and was discovered as an incidental finding by a dentist some months before. The patient’s medical history was not significant. Oral examination showed normal appearance and color of mucosa. Radiographic examination showed a well-defined, unilocular lesion extending in the left mandible anterior body (Fig. ). The lesion was extended in an intraradicular position, with superior limits ranging between the roots of the canine and the first and second premolar. The teeth were all vital. The lesion was subjected to surgical enucleation, and the material was sent for histopathological examination. Histological analysis of the lesion revealed a cyst wall with focally ciliated epithelium lining of variable thickness. The superficial layer of the epithelium showed metaplastic mucous cell with intraepithelial microcystic area (Fig. , and ). The results of immunohistochemistry revealed strong positive activity for CK 19 in all layer of the epithelium (Fig. ). The final diagnosis was glandular odontogenic cyst. The postoperative course was uneventful. Intraoral examination and radiographic evaluations by OPT every 6 months showed no recurrence during the 12 months follow-up period.

DISCUSSION

The Glandular odontogenic cyst is a rare lesion, with a frequency rate ranging from 0.012% [17] to 1.3% [18] of all jaw cists, and its prevalence is 0.17% [19].

The literature review took into consideration 110 previous cases, with one more additional case presented in this article (Table ). The main features of GOC are summarized in Table . The patient ages ranged from 11 to 90 years, and the majority of cases were reported in patient between 40 and 60 years of age (49 cases), with a mean age at diagnosis of 45.2 years (43.4 for males, 47.4 for females). The prevalence of this lesion was slightly more common in men, comprising 53.2% (59 cases).

Glandular odontogenic cyst had a clear preference for the mandible, with 74.8% of cases in this region and only 25.2% in the maxilla. The 48.6% of glandular odontogenic cysts (54 cases, 37 in the mandible and 17 in the maxilla) was found in the anterior regions, 18.9% (21 cases, 18 in the mandible and 3 in the maxilla) in the posterior regions, and the remaining 32.5% (36 cases, 28 in the mandible and 8 in the maxilla) of cases involved both the anterior and posterior areas, suggesting a predilection for the anterior areas of the jaws (Table ).

Swelling was the most common presenting manifestation of the GOC, reported in 76.3% of cases (74 cases, of which 60 were painless and 14 were associated with pain, probably due to pressure on neurovascular bundles [20]). In 9.3% of cases (9 cases), the only clinical manifestation was pain or discomfort. In 14.4% of cases, the GOC was asymptomatic (14 cases), and was discovered as an incidental finding. Other clinical manifestations were rare (inflammation / irritation of the overlying mucosa, tooth mobility / displacement, paresthesia) and can be associated with pain and / or swelling. No information was available on sign and symptoms for 13 cases.

Radiographically, the lesions typically presented as a radiolucent unilocular or multilocular lesion. These data highlights the absence of pathognomonic clinical or radiographic presentation of GOC, considering that the same features can be found in odontogenic keratocyst, unicystic or multicystic ameloblastoma, CMEC, lateral epithelial cyst and botryoid odontogenic cyst (BOC) [10]. The consequence was that the recognition of this cyst on base of physical and radiological examination was virtually impossible [8].

The histologenesis of GOC remain uncertain; in fact, it was initially suggested to develop from intraosseous salivary gland tissue [3]. Now most authors believe that these cysts originated from odontogenic epithelium [7, 21].

Histopathologically, some authors suggested that GOC may have a wide histologic spectrum ranging from cystic lesions resembling BOC to lesions resembling low-grade CMEC [22]. In particular, the differentiation of low-grade CMEC from multicystic GOC can be difficult to make, because significant histological overlap existed [5]. For these reasons, it has been suggested that many cases formerly diagnosed as CMEC can be examples of GOC as well as some low grade CMEC’s would have originate from GOC [8, 11].

Kaplan et al. [2] divided the microscopic characteristic of GOC into major and minor criteria, with the purpose of facilitate the diagnosis. According to this author, a certain diagnosis of GOC could be made with the presence of all the major signs. The major criteria include:

Squamous epithelial lining, with a flat interface with the connective tissue wall, lacking basal palisading.

Epithelium exhibiting variations in thickness along the cystic lining with or without epithelial “spheres” or “whorls” or focal luminal proliferation.

Cuboidal eosinophilic cells or “hob-nail” cells.

Mucous cells with intraepithelial mucous pools, with or without crypts lined by mucous-producing cells.

Intraepithelial glandular, microcystic or duct-like structures.

The minor criteria include:

Papillary proliferation of the lining epithelium.

Ciliated cells.

Multicystic or multiluminal architecture.

Clear or vacuolated cells in the basal or spinous layers.

However, the practical applicability of the above-suggested criteria may encounter some difficulties [23]. Moreover, some authors do not believe that all “major criteria” need to be present for diagnosis, but it is likely a combination of specific microscopic features to be important [23].

The present case showed some of the Kaplan’s histopathological criteria, such as the epithelium lining of variable thickness, mucous cells and intraepithelial microcystic area.

Due to the strong similarities between GOC and CMEC, immunohistochemistry may help diagnosis. Pires et al. [11]

have demonstrated that there are differences in the expression of CKs in GOC and CMEC, and suggested that CKs 18 and 19 could be useful in differentiating between these two lesions. Consistent with previous studies [11, 19, 22, 24], our results showed strong positivity in all layers of the epithelium for CK 19.

Many others molecular markers were investigated as new tools to diagnose GOC [25-28]. It has been suggested the use of Ki67 to distinguish GOC from CMEC [25]. Vered et al. [26] found levels of MASPIN (mammary serine protease inhibitor) significantly higher in the epithelial-mucous cells of CMEC than in GOC, that may help the differential diagnosis. Another marker was p63; immunostaining showed that this protein was confined to the basal and parabasal layers of the epithelium, with stained cells composed between 5% and 50% of the total [27].

Several methods of treatment of GOC, ranging from a conservative approach to a segmental resection, have been suggested [10], but the details of these surgical operations were not uniformly available. Furthermore, due to the rarity of the condition, treatment recommendations were not evidence based [15]. In 96 cases in which the surgical operations were reported, 86.5% of cysts (83 cases) were treated with a conservative method (like present case) while 13.5% (13 cases) received a more aggressive approach.

The reported recurrence of GOC was 19.8% (18 cases), but probably was an under-estimation, because 31 cases lacks follow-up informations. Furthermore, about 50% of cases had a very short follow-up, up to 2 years, while the average time for recurrence was 3 years. Therefore is important that patients with GOC maintain a long follow-up period, that should exceed 3 years, to precociously diagnose eventual recurrences, that can recur even after many years [29].

CONCLUSION

In terms of establishing a diagnosis of GOC, must be taken into consideration the fact that this is a rare lesion, and diagnosis can be extremely difficult due to the strong similarities with CMEC. It is also important that patients maintain a long follow-up period that could last up to 8 years.

Table 1.

Summary of clinical and radiological features, therapy, follow-up and eventual recurrence in 110 cases of glandular odontogenic cyst reported in the literature and the present case.

Author (Year)	Age/ Sex	Presentation	Region Affected (Teeth)	Radiological Features	Treatment	Follow-up	Recurr.	Interval Before Recurr.
Padayachee et al. (1987)	69/M	Swelling	Ant. Mand.	Multiloc. RL	Enucleation & curettage	4 y & 6 m	Yes	3 y
	71/F	Swelling	Ant. Mand.	Multiloc. RL	Enucleation & curettage	No	-	-
Gardner et al. (1988)	21/F	-	Max.(22-23)	Uniloc. RL	Enucleation	3 y & 6 m	No	-
	59/M	Swelling	Mand.(33-43)	RL	Enucleation	3 y & 8 m	Yes	3 y & 8 m
	44/F	-	Mand.(34-43)	RL	Enucleation	3 y & 3 m	Yes	3 y & 3 m
	85/F	-	Mand.(38-48)	Multiloc. RL	No	-	-	-
	59/M	-	Mand.(35-43)	RL	Curettage	6 m	No	-
	44/F	-	Max. (12-13)	RL	Enucleation	2 y	No	-
	19/M	Swelling	Mand.(36-43)	RL	Enucleation	1 y	No	-
	48/M	-	Ant. Mand.	RL	Enucleation	No	-	-
Lindh et al. (1990)	59/M	Swelling	Ant. Mand.	Multiloc. RL	Surgery	-	-	-
Ficarra et al. (1990)	64/F	Swelling, pain	Ant. Mand.	Multiloc. RL	Mandibular resection	2 y & 10 m	No	-
Sadeghi et al. (1991)	73/F	Swelling	Post. Mand.	Multiloc. RL	Enucleation	No	-	-
Patron et al. (1991)	45/M	Swelling	Mand.(31-45)	Uniloc. RL	Marginal mandibulec- tomy	20 y	No	-
	39/M	Swelling	Mand.(35-46)	Multiloc. RL root resorpt.	Enucleation	10 y	No	-
	52/M	Swelling	Max.(22-26)	Uniloc. RL, root resorpt.	Partial Maxillectomy	14 y	No	-
Van Heerden et al. (1992)	14/M	Swelling	Max.(12-13)	Uniloc. RL, tooth displ.	No	-	-	-
	27/F	Swelling	Mand.(36-45)	Uniloc. RL, tooth displ.	Enucleation	2 y	No	-
GÜnzl et al. (1993)	31/M	-	Ant. Mand.	Multiloc. RL	Excision	-	No	-
	39/M	-	Ant. Mand.	Multiloc. RL	Excision	-	No	-
	44/F	-	Post. Mand.	Multiloc. RL	Excision	-	No	-
	52/F	-	Post. Mand.	Multiloc. RL	Excision	-	No	-
Semba et al. (1994)	72/M	Swelling, pain	Mand.(32-35)	Multiloc. RL root resorpt.	Excision	2 y	No	-
Takeda et al. (1994)	29/M	Discomfort	Mand.(48)	Uniloc. RL	Extirpation	1 y & 2 m	No	-
De Carvalho et al. (1994)	56/F	Swelling	Mand.(34-36)	Multiloc. RL	Surgery	1 y	No	-
Toida et al. (1994)	50/F	Swelling	Mand.(34-42)	Multiloc. RL	Enucleation & curettage	3 y & 2 m	No	-
Hussain et al. (1995)	46/F	Swelling	Ant. Mand.	Multiloc. RL	Curettage	11 y	Yes	7 y
	44/F	Swelling	Mand.(41-34)	Multiloc. RL	Enucleation & curettage	No	-	-
	49/F	Discomfort	Mand.(41-35)	Multiloc. RL	Enucleation	2 y	No	-
	37/M	Pain	Mand.(36-46)	Multiloc. RL root resorpt.	Wide resection	3 y & 5 m	No	-
Economopoulou et al. (1995)	32/M	Swelling, pain	Max.(11-14)	Uniloc. RL	Curettage	1 y & 2 m	No	-
Ide et al. (1996)	54/F	asymptomatic	Mand.(33-42)	Uniloc. RL	Enucleation	1 y	No	-
Savage et al. (1996)	14/F	asymptomatic	Mand.(42-43)	Uniloc. RL	Enucleation	2 y	Yes	2 y
High et al. (1996)	41/F	asymptomatic	Mand.(43-36)	Multiloc. RL	Enucleation	9 y & 6 m	Yes	2 y; 7 y
	75/M	Swelling	Post. Mand.	Multiloc. RL	Surgery & cryotherapy	8 y	Yes	3 y; 5 y
	41/M	Swelling, pain	Mand.(36-46)	Multiloc. RL	Enucleation	11 y	Yes	8 y
	53/M	Discomfort	Mand.(33-44)	Uniloc. RL	Enucleation	1 y & 6 m	No	-
	53/F	Discomfort	Mand.(44-48)	RL, root resorpt.	Surgery	7 m	No	-
Magnusson et al. (1997)	60/M	asymptomatic	Mand.(42-43)	Uniloc. RL	Enucleation	8 y	No	-
	64/M	asymptomatic	Ant. Mand.	Uniloc. RL	Enucleation	10 y	No	-
	75/F	Ill-fitting denture	Mand.	Multiloc. RL	Enucleation	3 y	No	-
	30/M	Swelling, tooth displ.	Max.(11-21)	Uniloc. RL	Enucleation	2 y	Yes	1 y
	58/F	asymptomatic	Max.(33)	Uniloc. RL	Enucleation	2 y	No	-
	56/M	Swelling	Mand.(43-47)	Multiloc. RL tooth displ.	Enucleation	3 y	Yes	3 y
	46/F	asymptomatic	Mand.(33-43)	Multiloc. RL	Enucleation	6 m	Yes	6 m
Manojlović et al. (1997)	36/F	asymptomatic	Mand.(48)	Multiloc. RL	Curettage	2 y	No	-
Ramer et al. (1997)	90/F	Swelling, gin- gival irritation ill-fitting dentures	Mand.	Multiloc. RL	No	-	-	-
Machado de Sousa et al. (1997)	54/M	Swelling, pain erythematous ulcerated mucosa	Mand.(36-45)	Multiloc. RL tooth displ. root resorpt.	En bloc excision & cryotherapy	1 y	Yes	1 y
Koppang et al. (1998)	69/M	Swelling	Max.(11-13)	Uniloc. RL	Curettage	5 y & 7 m	Yes	2 y & 5 m
	43/M	Swelling, pain	Mand.(42-45)	Multiloc. RL	Excision & curettage	2 y & 1 m	No	-
Chavez et al. (1999)	70/M	Swelling	Ant. Mand.	Multiloc. RL	En bloc resection	-	-	-
Hisatomi et al. (2000)	45/F	Pain, tooth mobility	Mand.(43-45)	Uniloc. RL	Excision	-	-	-
Noffke et al. (2002)	50/M	Swelling	Mand.(34-43)	Uniloc. RL tooth displ.	-	-	No	-
	15/M	Swelling	Max.(22-23)	Uniloc. RL tooth displ.	-	-	No	-
	17/M	Swelling	Max.(12-17)	Uniloc. RL tooth displ.	-	-	No	-
	58/F	Swelling	Mand.(37-48)	Multiloc. RL tooth displ	-	-	No	-
	11/F	Swelling	Mand.(33-46)	Uniloc. RL tooth displ.	-	-	No	-
	59/F	Swelling	Mand.(47-48)	Uniloc. RL	-	-	No	-
	59/F	Swelling	Mand.(36-42)	Multiloc. RL tooth displ.	-	-	No	-
Ertaş et al. (2003)	70/M	Swelling	Mand.(35-44)	Multiloc. RL	Excision	-	-	-
Tran et al. (2004)	22/M	asymptomatic	Mand.(35-37)	Uniloc. RL	Enucleation	1 y & 6 m	No	-
Osny et al. (2004)	44/M	Pain	Mand.(32-36)	Multiloc. RL	Enucleation	1 y & 6 m	No	-
Abu-Id et al. (2005)	30/F	asymptomatic	Mand.	Multiloc. RL	Curettage	1 y & 3 m	-	-
Kaplan et al. (2005) Manor et al. (2003)	74/M	Swelling	Mand.	Uniloc. RL	Enucleation	10 y	No	-
	15/M	Swelling	Max.	Multiloc. RL root resorpt.	Partial Maxillec-tomy	5 y	No	-
	29/M	Swelling, parestesia	Max.	Uniloc. RL tooth displ.	Marsupiali-zation	6 y	No	-
	49/M	Swelling	Mand.	Uniloc. RL. tooth displ. root resorpt.	Enucleation	4 y	No	-
	25/F	Swelling	Ant. Max.	Uniloc. RL root resorpt.	Enucleation	4 y	No	-
	55/M	Swelling	Mand.	Uniloc. RL	Enucleation	2 y	No	-
	54/M	Swelling, tooth mobility	Max.	Uniloc. RL tooth displ.	Enucleation	3 y	yes	1 y
Qin et al. (2005) Wang et al. (1995)	30/F	Swelling	Mand.(44-47)	Uniloc. RL root resorpt.	Curettage	1 y & 8 m	No	-
	39/F	-	Mand.(32-46)	Multiloc. RL root resorpt.	En-bloc excision	5 y	No	-
	26/M	Swelling	Mand.(45-47)	Uniloc. RL root resorpt.	Curettage	1 m	No	-
	37/F	Swelling, pain	Max.(22-24)	Multiloc. RL tooth displ.	Curettage	1 y & 10 m	No	-
	52/F	Swelling	Max.(16-25)	Multiloc. RL	Curettage	5 y	No	-
	27/F	-	Max.(11-15)	Uniloc. RL	Curettage	No	-	-
	28/M	Swelling	Max.(21-27)	Uniloc. RL	Curettage	1 y & 10 m	No	-
	28/M	Swelling, pain	Max.(21/26)	Uniloc. RL	Curettage	3 y & 4 m	No	-
	40/M	Swelling	Max.(11-16)	Uniloc. RL	Curettage	5 y & 2 m	No	-
	25/M	Swelling	Max.(13-16)	Uniloc. RL	Curettage	1 y & 2 m	No	-
	22/M	-	Max.(21-23)	Uniloc. RL	Curettage	No	-	-
	35/M	Swelling	Mand.(45-47)	Uniloc. RL	Curettage	2 y & 6 m	No	-
	59/F	Swelling	Max.(13-15)	Uniloc. RL	Curettage	4 y	No	-
	49/M	Swelling	Mand.(36-43)	Uniloc. RL	Curettage	5 y	No	-
Velez et al. (2006)	36/F	Pain, tooth mobility	Mand.(37-44)	Multiloc. RL tooth displ.	Enucleation	-	-	-
	53/M	Pressure around teeth	Mand.(37-42)	Multiloc. RL	Enucleation	-	-	-
Kasaboğlu et al. (2006)	45/M	Swelling	Ant. Mand.	Uniloc. RL	Enucleation	6 m	No	-
Yoon et al. (2006)	66/F	Swelling, pain	Mand.	Uniloc. RL	Enucleation	1 y	No	-
Sittitavornwong et al. (2006)	57/F	Swelling	Max.(21-24)	Multiloc. RL tooth displ.	Excision	3 m	No	-
Thor et al. (2006)	38/F	Swelling, loss of sensibility, tooth displ.	Mand.(35-46)	Multiloc. RL	En-bloc ostectomy	10 y	-	-
Nair et al. (2006)	45/F	Swelling, pain	Max.(16-18)	Uniloc. RL	Enucleation	No	-	-
Foss et al. (2007)	46/F	asymptomatic	Ant. Mand.	Multiloc. RL	Segmental Mandibu-lectomy	No	-	-
de Castro et al. (2008)	40/F	Swelling	Mand.(32-41)	Uniloc. RL	Enucleation	1 y	No	-
Kumaraswamy et al. (2008)	14/M	Swelling, pain	Mand.(43-48)	Uniloc. RL root resorpt. tooth displ.	Enucleation	1 y	No	-
Manzini et al. (2009)	27/F	Pain, pruritus, inflammated mucosa	Ant. Max.	Uniloc. RL	Enucleation	No	-	-
Oliveira et al. (2009)	54/F	Swelling	Mand.(31-35)	Multiloc. RL	Enucleation	9 m	Yes	9 m
Krishnamurthy et al. (2009)	42/F	Swelling	Mand.(36-45)	Multiloc. RL	En-bloc resection	2 y	No	-
	21/M	Swelling	Mand.(32-38)	Multiloc. RL	En-bloc resection	2 y	No	-
Prabhu et al. (2010)	47/F	Swelling	Max.	Uniloc. RL	Enucleation	5 y	No	-
Lyrio et al. (2010)	37/M	Swelling	Mand.(41-48)	Multiloc. RL	Curettage	No	-	-
Booth et al. (2010)	36/M	asymptomatic	Mand.(48)	Uniloc. RL	Surgical removal	6 m	Yes	6 m
Boffano et al. (2010)	68/M	Swelling	Mand.(33-47)	Multiloc. RL	Curettage	2 y	No	-
	82/F	Swelling, paresthesia	Post. Mand.	Uniloc. RL	En-bloc excision	6 y	No	-
Cano et al. (2011)	54/M	Swelling	Mand.(45-48)	Multiloc. RL	curettage	3 y	No	-
	63/F	Swelling	Mand.(36-47)	Multiloc. RL	Marsupiali-zation	3 y	No	-
Korkmaz et al. (2011)	52/M	asymptomatic	Mand.	Multiloc. RL	Curettage	6 y	No	-
Salehinejad et al. (2011)	28/M	Swelling	Mand.(45-47)	Uniloc. RL root resorpt.	Enucleation	2 y	No	-
Amberkar et al. (2011)	29/M	Swelling, pain	Max.(13-17, 23-27)	Uniloc. RL	-	-	-	-
Guruprasad et al. (2011)	17/F	Swelling, pain	Post. Max.	Uniloc. RL	Enucleation & curettage	1 y	No	-
AraÚjo de Morais (2012)	56/M	Swelling, pain	Mand.(41-45)	Uniloc. RL	Enucleation & curettage	8 m	No	-
Present case	38/F	asymptomatic	Mand.(33-35)	Uniloc. RL	Enucleation	12 m	No	-

RL=radiolucency; Multiloc.=multilocular; Uniloc.=unilocular; Ant. Mand.=anterior mandible; Post. Mand.= posterior mandible; Ant. Max.=anterior maxilla; Post. Max=posterior maxilla; resorpt..=resorption; displ.=displacement; y=year; m=month;

Table 2.

GOC main features.

Mean Age	45.2 Years
Gender	53% males 47% females
Place	74.8% Mandible 25.2% Maxilla
Clinical presentation	75.3% painful/painless swelling 14.4% asymptomatic 9.3% pain/discomfort
Radiographic features	51.0% unilocular 49.0% multilocular
Treatment	86.5% conservative 13.5% aggressive
Mean follow-up period	3 years and 7 months
Recurrence	19.8% of cases (3 years)

Table 3.

GOC location.

	Mand.	Max.	Mand. & Max.
Ant.	33.3%	15.3%	48.6%
Post.	16.2%	2.7%	18.9%
Ant.&Post.	25.2%	7.3%	32.5%
Total	74.8%	25.2%	100.0%

Ant.=anterior; Post.=posterior; Mand.=mandible; Max.=maxilla