Vincent L Biron1, Eric J Lentsch2, Daniel R Gerry2,3, Arnaud F Bewley1. 1. Department of Otolaryngology, University of California Davis, Sacramento, California. 2. Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina. 3. Mercer University School of Medicine, Savannah, Georgia.
Abstract
BACKGROUND: Acinic cell carcinoma is an uncommon salivary neoplasm with clinical and histologic features known to influence prognosis. The purpose of this study was to further describe variables influencing survival in a large cohort of patients with acinic cell carcinoma. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) registry, we obtained demographic, clinicopathologic, and treatment data pertaining to patients diagnosed with acinic cell carcinoma. Kaplan-Meier and Cox regression analyses were performed to compare survival with various clinical and pathological parameters. RESULTS: We identified 2061 patients with acinic cell carcinoma from 1973 to 2009. Sex, staging, grade, subsite, and treatment were significant predictors of disease-specific survival (DSS). Patients who received surgery alone had the highest 20-year DSS (92.4%), followed by those treated with surgery and radiation (71.9%) or radiation alone (62.3%). CONCLUSION: Our results suggest that histologic grade is a stronger predictor of survival than TNM classification, survival after surgical resection alone is excellent, and adjuvant radiation may be of limited benefit
BACKGROUND:Acinic cell carcinoma is an uncommon salivary neoplasm with clinical and histologic features known to influence prognosis. The purpose of this study was to further describe variables influencing survival in a large cohort of patients with acinic cell carcinoma. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) registry, we obtained demographic, clinicopathologic, and treatment data pertaining to patients diagnosed with acinic cell carcinoma. Kaplan-Meier and Cox regression analyses were performed to compare survival with various clinical and pathological parameters. RESULTS: We identified 2061 patients with acinic cell carcinoma from 1973 to 2009. Sex, staging, grade, subsite, and treatment were significant predictors of disease-specific survival (DSS). Patients who received surgery alone had the highest 20-year DSS (92.4%), followed by those treated with surgery and radiation (71.9%) or radiation alone (62.3%). CONCLUSION: Our results suggest that histologic grade is a stronger predictor of survival than TNM classification, survival after surgical resection alone is excellent, and adjuvant radiation may be of limited benefit
Authors: V Vander Poorten; A Triantafyllou; L D R Thompson; J Bishop; E Hauben; J Hunt; A Skalova; G Stenman; R P Takes; D R Gnepp; H Hellquist; B Wenig; D Bell; A Rinaldo; A Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2015-12-19 Impact factor: 2.503
Authors: Erin A Kaya; Zachary C Taylor; Brian J Mitchell; Zachary D Guss; Jeffrey D Bunn; Robert K Fairbanks; Wayne T Lamoreaux; Aaron E Wagner; Ben J Peressini; Christopher M Lee Journal: World J Oncol Date: 2020-10-15
Authors: Maximilian P Schmid; Thomas Held; Kristin Lang; Klaus Herfarth; Juliane Hörner-Rieber; Semi B Harrabi; Julius Moratin; Christian Freudlsperger; Karim Zaoui; Jürgen Debus; Sebastian Adeberg Journal: Cancers (Basel) Date: 2021-01-02 Impact factor: 6.639