Literature DB >> 24623609

Oncologic outcomes of total laryngectomy: impact of margins and preoperative tracheostomy.

Naveed Basheeth1, Gerard O'Leary1, Habib Khan1, Patrick Sheahan1.   

Abstract

BACKGROUND: The purpose of this present study was to investigate risk factors for local recurrence and death after total laryngectomy, with particular emphasis on pattern of local recurrence (stomal vs pharyngeal/base of tongue) and impact of preceding tracheostomy.
METHODS: We conducted a retrospective review of 75 consecutive total laryngectomies for cancer of the larynx.
RESULTS: Nineteen patients underwent preoperative tracheostomy, which was a significant risk factor for local recurrence (p = .04). With regard to pattern of local recurrence, preoperative tracheostomy (p = .03) and pathological nodal status (pN+; p = .04) were significant for stomal, but not pharyngeal recurrence; whereas positive margins (p = .01) was significant for pharyngeal, but not stomal recurrence. Preoperative tracheostomy, pN+, lymphovascular invasion, and positive margins were all significant for survival.
CONCLUSION: Preoperative tracheostomy continues to be a significant adverse prognosticator in patients undergoing total laryngectomy. Our findings also suggest distinct causative factors for different patterns of postlaryngectomy local recurrence.
© 2014 Wiley Periodicals, Inc.

Entities:  

Keywords:  carcinoma; laryngectomy; larynx; local neoplasm recurrence; squamous cell; tracheostomy

Mesh:

Year:  2014        PMID: 24623609     DOI: 10.1002/hed.23681

Source DB:  PubMed          Journal:  Head Neck        ISSN: 1043-3074            Impact factor:   3.147


  7 in total

1.  Association of Positive Initial Margins With Survival Among Patients With Squamous Cell Carcinoma Treated With Total Laryngectomy.

Authors:  Patrick Tassone; Corey Savard; Michael C Topf; William Keane; Adam Luginbuhl; Joseph Curry; David Cognetti
Journal:  JAMA Otolaryngol Head Neck Surg       Date:  2018-11-01       Impact factor: 6.223

2.  Preoperative Tracheostomy Is Associated with Poor Disease-Free Survival in Recurrent Laryngeal Cancer.

Authors:  Andrew C Birkeland; Andrew J Rosko; Lauren Beesley; Emily Bellile; Steven B Chinn; Andrew G Shuman; Mark E Prince; Gregory T Wolf; Carol R Bradford; J Chad Brenner; Matthew E Spector
Journal:  Otolaryngol Head Neck Surg       Date:  2017-06-06       Impact factor: 3.497

3.  Laser debulking or tracheotomy in airway management prior to total laryngectomy for T4a laryngeal cancer.

Authors:  Djamil Semdaie; Fabienne Haroun; Odile Casiraghi; François Bidault; Stéphane Temam; François Janot; Philippe Gorphe
Journal:  Eur Arch Otorhinolaryngol       Date:  2018-05-18       Impact factor: 2.503

Review 4.  Tissue-Engineered Larynx: Future Applications in Laryngeal Cancer.

Authors:  Nick J I Hamilton; Martin A Birchall
Journal:  Curr Otorhinolaryngol Rep       Date:  2017-03-14

5.  Survival Outcomes and Predictors for Patients who Failed Chemoradiotherapy/Radiotherapy and Underwent Salvage Total Laryngectomy.

Authors:  Ming-Hsien Tsai; Hui-Ching Chuang; Yu-Tsai Lin; Tai-Lin Huang; Fu-Min Fang; Hui Lu; Chih-Yen Chien
Journal:  Int J Environ Res Public Health       Date:  2021-01-06       Impact factor: 3.390

6.  Management of advanced laryngeal cancer.

Authors:  Patrick Sheahan
Journal:  Rambam Maimonides Med J       Date:  2014-04-28

7.  Prognostic role of resection margin in open oncologic laryngeal surgery: survival analysis of a cohort of 139 patients affected by squamous cell carcinoma.

Authors:  Carmelo Saraniti; Riccardo Speciale; Salvatore Gallina; Pietro Salvago
Journal:  Braz J Otorhinolaryngol       Date:  2018-06-02
  7 in total

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