Literature DB >> 24623477

Prediction of passive drug permeability across the blood-retinal barrier.

Aapo Tervonen1, Iina Vainio, Soile Nymark, Jari Hyttinen.   

Abstract

PURPOSE: The purpose of this study is to develop a computational model of the physical barrier function of the outer blood-retinal barrier (BRB), which is vital for normal retinal function. To our best knowledge no comprehensive models of BRB has been reported.
METHODS: The model construction is based on the three-layered structure of the BRB: retinal pigment epithelium (RPE), Bruch's membrane and choriocapillaris endothelium. Their permeabilities were calculated based on the physical theories and experimental material and permeability studies in the literature, which were used to describe diffusional hindrance in specific environments.
RESULTS: Our compartmental BRB model predicts permeabilities with magnitudes similar to the experimental values in the literature. However, due to the small number and varying experimental conditions there is a large variability in the available experimental data, rendering validation of the model difficult. The model suggests that the paracellular pathway of the RPE largely defines the total BRB permeability.
CONCLUSIONS: Our model is the first BRB model of its level and combines the present knowledge of the BRB barrier function. Furthermore, the model forms a platform for the future model development to be used for the design of new drugs and drug administration systems.

Mesh:

Year:  2014        PMID: 24623477     DOI: 10.1007/s11095-014-1325-3

Source DB:  PubMed          Journal:  Pharm Res        ISSN: 0724-8741            Impact factor:   4.200


  37 in total

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2.  Na,K-ATPase inhibition alters tight junction structure and permeability in human retinal pigment epithelial cells.

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3.  Apical and basal regulation of the permeability of the retinal pigment epithelium.

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5.  Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomers.

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6.  A dual-pathway ultrastructural model for the tight junction of rat proximal tubule epithelium.

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Review 7.  Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex.

Authors:  Imran Bhutto; Gerard Lutty
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8.  Modeling of corneal and retinal pharmacokinetics after periocular drug administration.

Authors:  Aniruddha C Amrite; Henry F Edelhauser; Uday B Kompella
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9.  Lateral diffusion of lipids in complex biological membranes.

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10.  Primordium of an artificial Bruch's membrane made of nanofibers for engineering of retinal pigment epithelium cell monolayers.

Authors:  Patrick H Warnke; Mohammad Alamein; Stuart Skabo; Sebastien Stephens; Robert Bourke; Peter Heiner; Qin Liu
Journal:  Acta Biomater       Date:  2013-08-02       Impact factor: 8.947

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  3 in total

Review 1.  Mechanistic Pathogenesis of Endothelial Dysfunction in Diabetic Nephropathy and Retinopathy.

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2.  Structural dynamics of tight junctions modulate the properties of the epithelial barrier.

Authors:  Aapo Tervonen; Teemu O Ihalainen; Soile Nymark; Jari Hyttinen
Journal:  PLoS One       Date:  2019-04-09       Impact factor: 3.240

3.  Influences of advanced glycosylation end products on the inner blood-retinal barrier in a co-culture cell model in vitro.

Authors:  Chen Yuan; Ya Mo; Jie Yang; Mei Zhang; Xuejun Xie
Journal:  Open Life Sci       Date:  2020-08-24       Impact factor: 0.938

  3 in total

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