Literature DB >> 24623412

The C-terminal repeat domains of nsP3 from the Old World alphaviruses bind directly to G3BP.

Marc D Panas1, Tero Ahola, Gerald M McInerney.   

Abstract

The Old World alphaviruses block stress granule assembly by sequestration of RasGAP SH3-domain binding protein (G3BP). Here, we show that the proline-rich sequences in the hypervariable domain of nonstructural protein 3 (nsP3) of both Semliki Forest virus and Chikungunya virus were dispensable for binding to G3BP. nsP3 variants with or without this domain colocalized with G3BP. Furthermore, we show that the C-terminal repeat motifs of nsP3 were sufficient for G3BP binding.

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Year:  2014        PMID： 24623412      PMCID： PMC4019107          DOI： 10.1128/JVI.00439-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  22 in total

1.  Tracking and elucidating alphavirus-host protein interactions.

Authors:  Ileana M Cristea; John-William N Carroll; Michael P Rout; Charles M Rice; Brian T Chait; Margaret R MacDonald
Journal:  J Biol Chem       Date:  2006-08-08       Impact factor: 5.157

2.  Elimination of phosphorylation sites of Semliki Forest virus replicase protein nsP3.

Authors:  H Vihinen; T Ahola; M Tuittila; A Merits; L Kääriäinen
Journal:  J Biol Chem       Date:  2000-12-04       Impact factor: 5.157

3.  Nonstructural proteins nsP3 and nsP4 of Ross River and O'Nyong-nyong viruses: sequence and comparison with those of other alphaviruses.

Authors:  E G Strauss; R Levinson; C M Rice; J Dalrymple; J H Strauss
Journal:  Virology       Date:  1988-05       Impact factor: 3.616

4.  Complete sequence of Venezuelan equine encephalitis virus subtype IE reveals conserved and hypervariable domains within the C terminus of nsP3.

Authors:  M S Oberste; M D Parker; J F Smith
Journal:  Virology       Date:  1996-05-01       Impact factor: 3.616

5.  Formation of nsP3-specific protein complexes during Sindbis virus replication.

Authors:  Elena Frolova; Rodion Gorchakov; Natalia Garmashova; Svetlana Atasheva; Leoncio A Vergara; Ilya Frolov
Journal:  J Virol       Date:  2006-04       Impact factor: 5.103

6.  Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation.

Authors:  Gerald M McInerney; Nancy L Kedersha; Randal J Kaufman; Paul Anderson; Peter Liljeström
Journal:  Mol Biol Cell       Date:  2005-06-01       Impact factor: 4.138

7.  The Old World and New World alphaviruses use different virus-specific proteins for induction of transcriptional shutoff.

Authors:  Natalia Garmashova; Rodion Gorchakov; Eugenia Volkova; Slobodan Paessler; Elena Frolova; Ilya Frolov
Journal:  J Virol       Date:  2006-11-15       Impact factor: 5.103

8.  Semliki Forest virus nonstructural protein 2 is involved in suppression of the type I interferon response.

Authors:  Lucy Breakwell; Pia Dosenovic; Gunilla B Karlsson Hedestam; Mauro D'Amato; Peter Liljeström; John Fazakerley; Gerald M McInerney
Journal:  J Virol       Date:  2007-06-06       Impact factor: 5.103

9.  Deletions in the hypervariable domain of the nsP3 gene attenuate Semliki Forest virus virulence.

Authors:  Sareen E Galbraith; Brian J Sheahan; Gregory J Atkins
Journal:  J Gen Virol       Date:  2006-04       Impact factor: 3.891

10.  Hypervariable domain of nonstructural protein nsP3 of Venezuelan equine encephalitis virus determines cell-specific mode of virus replication.

Authors:  Niall J Foy; Maryna Akhrymuk; Alexander V Shustov; Elena I Frolova; Ilya Frolov
Journal:  J Virol       Date:  2013-05-01       Impact factor: 5.103
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  52 in total

1.  Stress granule formation, disassembly, and composition are regulated by alphavirus ADP-ribosylhydrolase activity.

Authors:  Aravinth Kumar Jayabalan; Srivathsan Adivarahan; Aakash Koppula; Rachy Abraham; Mona Batish; Daniel Zenklusen; Diane E Griffin; Anthony K L Leung
Journal:  Proc Natl Acad Sci U S A       Date:  2021-02-09       Impact factor: 11.205

2.  Mutations in Hypervariable Domain of Venezuelan Equine Encephalitis Virus nsP3 Protein Differentially Affect Viral Replication.

Authors:  Chetan D Meshram; Aaron T Phillips; Tetyana Lukash; Nikita Shiliaev; Elena I Frolova; Ilya Frolov
Journal:  J Virol       Date:  2020-01-17       Impact factor: 5.103

3.  The Host DHX9 DExH-Box Helicase Is Recruited to Chikungunya Virus Replication Complexes for Optimal Genomic RNA Translation.

Authors:  Roy Matkovic; Eric Bernard; Jean-Marie Péloponèse; Simon Fontanel; Patrick Eldin; Nathalie Chazal; Deka Hassan Hersi; Andres Merits; Laurence Briant
Journal:  J Virol       Date:  2019-02-05       Impact factor: 5.103

Review 4.  Chikungunya fever: a threat to global public health.

Authors:  Raíza Nara Cunha Moizéis; Thales Allyrio Araújo de Medeiros Fernandes; Paulo Marcos da Matta Guedes; Hannaly Wana Bezerra Pereira; Daniel Carlos Ferreira Lanza; Judson Welber Veríssimo de Azevedo; Josélio Maria de Araújo Galvão; José Veríssimo Fernandes
Journal:  Pathog Glob Health       Date:  2018-05-28       Impact factor: 2.894

5.  Identification and Characterization of Sindbis Virus RNA-Host Protein Interactions.

Authors:  Autumn T LaPointe; Natasha N Gebhart; Megan E Meller; Richard W Hardy; Kevin J Sokoloski
Journal:  J Virol       Date:  2018-03-14       Impact factor: 5.103

6.  Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2.

Authors:  Age Utt; Pratyush Kumar Das; Margus Varjak; Valeria Lulla; Aleksei Lulla; Andres Merits
Journal:  J Virol       Date:  2014-12-31       Impact factor: 5.103

7.  Hypervariable Domain of Eastern Equine Encephalitis Virus nsP3 Redundantly Utilizes Multiple Cellular Proteins for Replication Complex Assembly.

Authors:  Ilya Frolov; Dal Young Kim; Maryna Akhrymuk; James A Mobley; Elena I Frolova
Journal:  J Virol       Date:  2017-06-26       Impact factor: 5.103

8.  Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization.

Authors:  Bastian Thaa; Roberta Biasiotto; Kai Eng; Maarit Neuvonen; Benjamin Götte; Lara Rheinemann; Margit Mutso; Age Utt; Finny Varghese; Giuseppe Balistreri; Andres Merits; Tero Ahola; Gerald M McInerney
Journal:  J Virol       Date:  2015-09-02       Impact factor: 5.103

9.  Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein.

Authors:  Tetyana Lukash; Tatiana Agback; Francisco Dominguez; Nikita Shiliaev; Chetan Meshram; Elena I Frolova; Peter Agback; Ilya Frolov
Journal:  J Virol       Date:  2020-12-09       Impact factor: 5.103

10.  Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization.

Authors:  David W Sanders; Nancy Kedersha; Daniel S W Lee; Amy R Strom; Victoria Drake; Joshua A Riback; Dan Bracha; Jorine M Eeftens; Allana Iwanicki; Alicia Wang; Ming-Tzo Wei; Gena Whitney; Shawn M Lyons; Paul Anderson; William M Jacobs; Pavel Ivanov; Clifford P Brangwynne
Journal:  Cell       Date:  2020-04-16       Impact factor: 41.582
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