OBJECTIVE: To determine the risk factors for developing candida infections in pediatric intensive care unit (PICU). METHODS: The present study was conducted as a case-control study and included the population of patients who were admitted to PICU during the period of March 2010-March 2011. RESULTS: During the study period, a total of 57 patients in PICU had candidemia, 4 cases were excluded due to their PICU stay less than 48 h and one due to the insufficient data. The most commonly isolated Candida species was C. albicans, followed by C. parapsilosis. The median duration of hospitalization in PICU was higher (22.0 d) in candidemia patients compared to control group (13.5 d) (p = 0.037). The patients with candidemia had higher rates of presence of mechanical ventilation, presence of central venous catheter, and being under total parenteral nutrition; compared to the control group. CONCLUSIONS: The longer PICU durations, mechanical ventilation, central venous catheter, total parenteral nutrition were the associated factors. Although trials for predicitive models or scoring systems for development of candidemia have been performed; more future studies were required for practical usage in clinics settings in order to prevent candidemia.
OBJECTIVE: To determine the risk factors for developing candida infections in pediatric intensive care unit (PICU). METHODS: The present study was conducted as a case-control study and included the population of patients who were admitted to PICU during the period of March 2010-March 2011. RESULTS: During the study period, a total of 57 patients in PICU had candidemia, 4 cases were excluded due to their PICU stay less than 48 h and one due to the insufficient data. The most commonly isolated Candida species was C. albicans, followed by C. parapsilosis. The median duration of hospitalization in PICU was higher (22.0 d) in candidemiapatients compared to control group (13.5 d) (p = 0.037). The patients with candidemia had higher rates of presence of mechanical ventilation, presence of central venous catheter, and being under total parenteral nutrition; compared to the control group. CONCLUSIONS: The longer PICU durations, mechanical ventilation, central venous catheter, total parenteral nutrition were the associated factors. Although trials for predicitive models or scoring systems for development of candidemia have been performed; more future studies were required for practical usage in clinics settings in order to prevent candidemia.
Authors: Javier Pemán; Emilia Cantón; María José Linares-Sicilia; Eva María Roselló; Nuria Borrell; María Teresa Ruiz-Pérez-de-Pipaon; Jesús Guinea; Julio García; Aurelio Porras; Ana María García-Tapia; Luisa Pérez-Del-Molino; Anabel Suárez; Julia Alcoba; Inmaculada García-García Journal: J Clin Microbiol Date: 2011-10-19 Impact factor: 5.948
Authors: A S Levin; S F Costa; N S Mussi; M Basso; S I Sinto; C Machado; D C Geiger; M C Villares; A Z Schreiber; A A Barone; M L Branchini Journal: Diagn Microbiol Infect Dis Date: 1998-04 Impact factor: 2.803
Authors: Theoklis E Zaoutis; Susan E Coffin; Jaclyn H Chu; Kateri Heydon; Huaqing Zhao; H Mollie Greves; Thomas J Walsh Journal: Pediatr Infect Dis J Date: 2005-08 Impact factor: 2.129
Authors: M A Pfaller; D J Diekema; R N Jones; H S Sader; A C Fluit; R J Hollis; S A Messer Journal: J Clin Microbiol Date: 2001-09 Impact factor: 5.948
Authors: Christopher C Blyth; Sharon C A Chen; Monica A Slavin; Carol Serena; Quoc Nguyen; Deborah Marriott; David Ellis; Wieland Meyer; Tania C Sorrell Journal: Pediatrics Date: 2009-05 Impact factor: 7.124