Literature DB >> 24621829

Degradation of specific nuclear proteins occurs in the cytoplasm in Saccharomyces cerevisiae.

Li Chen1, Kiran Madura.   

Abstract

The ubiquitin/proteasome system has been characterized extensively, although the site of nuclear substrate turnover has not been established definitively. We report here that two well-characterized nuclear proteins are stabilized in nuclear export mutants in Saccharomyces cerevisiae. The requirement for nuclear export defines a new regulatory step in intracellular proteolysis.

Entities:  

Keywords:  degradation; export; proteasome; substrate; ubiquitin

Mesh：

Substances：

Year:  2014        PMID： 24621829      PMCID： PMC4012479          DOI： 10.1534/genetics.114.163824

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


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