Literature DB >> 24621346

Luliconazole: a review of a new antifungal agent for the topical treatment of onychomycosis.

Richard K Scher1, Norifumi Nakamura, Amir Tavakkol.   

Abstract

Luliconazole is a novel, broad-spectrum, imidazole antifungal under development in the USA as a treatment for dermatophytic skin and nail infections. In vitro, luliconazole is one of the most potent antifungal agents against filamentous fungi including dermatophytes. Luliconazole has been formulated in a 10% solution with unique molecular properties, which allow it to penetrate the nail plate and rapidly achieve fungicidal levels in the nail unit. These properties make luliconazole a potent compound in the treatment of onychomycosis. This article reviews the development of luliconazole solution, 10% its molecular properties, preclinical and clinical data and its future perspectives for the treatment of fungal infections.
© 2014 Blackwell Verlag GmbH.

Entities:  

Keywords:  Luliconazole; Trichophyton rubrum; antifungal; dermatophyte; onychomycosis; topical

Mesh：

Substances：

Year:  2014        PMID： 24621346     DOI： 10.1111/myc.12168

Source DB:  PubMed          Journal:  Mycoses        ISSN： 0933-7407            Impact factor:   4.377


  11 in total

Review 1.  Antibiofilm Treatment for Onychomycosis and Chronic Fungal Infections.

Authors:  Aditya K Gupta; Jessie Carviel; Neil H Shear
Journal:  Skin Appendage Disord       Date:  2017-10-11

2.  Molecular identification, biofilm formation and antifungal susceptibility of Rhodotorula spp.

Authors:  Maral Gharaghani; Simin Taghipour; Ali Zarei Mahmoudabadi
Journal:  Mol Biol Rep       Date:  2020-11-01       Impact factor: 2.316

Review 3.  Nitrile-containing pharmaceuticals: target, mechanism of action, and their SAR studies.

Authors:  Xi Wang; Yuanxun Wang; Xuemin Li; Zhenyang Yu; Chun Song; Yunfei Du
Journal:  RSC Med Chem       Date:  2021-08-10

4.  Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole against a Collection of Azole-Resistant and -Susceptible Aspergillus fumigatus Strains.

Authors:  Mahdi Abastabar; Nooshin Rahimi; Jacques F Meis; Narges Aslani; Sadegh Khodavaisy; Mojtaba Nabili; Ali Rezaei-Matehkolaei; Koichi Makimura; Hamid Badali
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

Review 5.  New Antifungal Agents and New Formulations Against Dermatophytes.

Authors:  Aditya K Gupta; Kelly A Foley; Sarah G Versteeg
Journal:  Mycopathologia       Date:  2016-08-08       Impact factor: 2.574

Review 6.  Luliconazole for the treatment of fungal infections: an evidence-based review.

Authors:  Deepshikha Khanna; Subhash Bharti
Journal:  Core Evid       Date:  2014-09-24

7.  Efficacy Coefficients Determined Using Nail Permeability and Antifungal Activity in Keratin-Containing Media Are Useful for Predicting Clinical Efficacies of Topical Drugs for Onychomycosis.

Authors:  Yoshiki Matsuda; Keita Sugiura; Takashi Hashimoto; Akane Ueda; Yoshihiro Konno; Yoshiyuki Tatsumi
Journal:  PLoS One       Date:  2016-07-21       Impact factor: 3.240

Review 8.  Onychomycosis: A Review.

Authors:  Bianca Maria Piraccini; Aurora Alessandrini
Journal:  J Fungi (Basel)       Date:  2015-03-27

9.  A 23 bp cyp51A Promoter Deletion Associated With Voriconazole Resistance in Clinical and Environmental Isolates of Neocosmospora keratoplastica.

Authors:  Jasper Elvin James; Erwin Lamping; Jacinta Santhanam; Trudy Jane Milne; Mohd Fuat Abd Razak; Latiffah Zakaria; Richard David Cannon
Journal:  Front Microbiol       Date:  2020-03-31       Impact factor: 5.640

10.  The potency of luliconazole against clinical and environmental Aspergillus nigri complex.

Authors:  Sahar Hivary; Mahnaz Fatahinia; Marzieh Halvaeezadeh; Ali Zarei Mahmoudabadi
Journal:  Iran J Microbiol       Date:  2019-12
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