Literature DB >> 24619065

One-pot hydrazide-based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin-1.

Man Pan1, Yao He, Ming Wen, Fangming Wu, Demeng Sun, Sijian Li, Longhua Zhang, Yiming Li, Changlin Tian.   

Abstract

An efficient one-pot chemical synthesis of snake venom toxin Mambalgin-1 was achieved using an azide-switch strategy combined with hydrazide-based native chemical ligation. Synthetic Mambalgin-1 exhibited a well-defined structure after sequential folding in vitro. NMR spectroscopy revealed a three-finger toxin family structure, and the synthetic toxin inhibited human acid-sensing ion channel 1a.

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Year:  2014        PMID： 24619065     DOI： 10.1039/c4cc00779d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition.

Authors:  Gilles Mourier; Miguel Salinas; Pascal Kessler; Enrico A Stura; Mathieu Leblanc; Livia Tepshi; Thomas Besson; Sylvie Diochot; Anne Baron; Dominique Douguet; Eric Lingueglia; Denis Servent
Journal:  J Biol Chem       Date:  2015-12-17       Impact factor: 5.157

2.  Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.

Authors:  Sónia Troeira Henriques; Evelyne Deplazes; Nicole Lawrence; Olivier Cheneval; Stephanie Chaousis; Marco Inserra; Panumart Thongyoo; Glenn F King; Alan E Mark; Irina Vetter; David J Craik; Christina I Schroeder
Journal:  J Biol Chem       Date:  2016-06-16       Impact factor: 5.157

3.  Cryo-EM structure of the ASIC1a-mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect.

Authors:  Demeng Sun; You Yu; Xiaobin Xue; Man Pan; Ming Wen; Siyu Li; Qian Qu; Xiaorun Li; Longhua Zhang; Xueming Li; Lei Liu; Maojun Yang; Changlin Tian
Journal:  Cell Discov       Date:  2018-06-05       Impact factor: 10.849

4.  Redox-Controlled Chemical Protein Synthesis: Sundry Shades of Latency.

Authors:  Vangelis Agouridas; Nathalie Ollivier; Jérôme Vicogne; Vincent Diemer; Oleg Melnyk
Journal:  Acc Chem Res       Date:  2022-09-09       Impact factor: 24.466

5.  Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1.

Authors:  Demeng Sun; Sanling Liu; Siyu Li; Mengge Zhang; Fan Yang; Ming Wen; Pan Shi; Tao Wang; Man Pan; Shenghai Chang; Xing Zhang; Longhua Zhang; Changlin Tian; Lei Liu
Journal:  Elife       Date:  2020-09-11       Impact factor: 8.140

Review 6.  Opportunities for Expanding Encoded Chemical Diversification and Improving Hit Enrichment in mRNA-Displayed Peptide Libraries.

Authors:  Paddy R A Melsen; Ryoji Yoshisada; Seino A K Jongkees
Journal:  Chembiochem       Date:  2022-02-18       Impact factor: 3.461

7.  A simple and traceless solid phase method simplifies the assembly of large peptides and the access to challenging proteins.

Authors:  N Ollivier; R Desmet; H Drobecq; A Blanpain; E Boll; B Leclercq; A Mougel; J Vicogne; O Melnyk
Journal:  Chem Sci       Date:  2017-05-30       Impact factor: 9.825

8.  Efficient Chemical Protein Synthesis using Fmoc-Masked N-Terminal Cysteine in Peptide Thioester Segments.

Authors:  Abhisek Kar; Jamsad Mannuthodikayil; Sameer Singh; Anamika Biswas; Puneet Dubey; Amit Das; Kalyaneswar Mandal
Journal:  Angew Chem Int Ed Engl       Date:  2020-05-26       Impact factor: 16.823
  8 in total

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