| Literature DB >> 24618891 |
Thomas W Mühleisen1, Markus Leber2, Thomas G Schulze3, Jana Strohmaier4, Franziska Degenhardt5, Jens Treutlein4, Manuel Mattheisen6, Andreas J Forstner5, Johannes Schumacher5, René Breuer4, Sandra Meier7, Stefan Herms8, Per Hoffmann9, André Lacour10, Stephanie H Witt4, Andreas Reif11, Bertram Müller-Myhsok12, Susanne Lucae13, Wolfgang Maier14, Markus Schwarz15, Helmut Vedder15, Jutta Kammerer-Ciernioch15, Andrea Pfennig16, Michael Bauer16, Martin Hautzinger17, Susanne Moebus18, Lutz Priebe5, Piotr M Czerski19, Joanna Hauser19, Jolanta Lissowska20, Neonila Szeszenia-Dabrowska21, Paul Brennan22, James D McKay23, Adam Wright24, Philip B Mitchell24, Janice M Fullerton25, Peter R Schofield25, Grant W Montgomery26, Sarah E Medland26, Scott D Gordon26, Nicholas G Martin26, Valery Krasnow27, Alexander Chuchalin28, Gulja Babadjanova28, Galina Pantelejeva29, Lilia I Abramova29, Alexander S Tiganov29, Alexey Polonikov30, Elza Khusnutdinova31, Martin Alda32, Paul Grof33, Guy A Rouleau34, Gustavo Turecki35, Catherine Laprise36, Fabio Rivas37, Fermin Mayoral37, Manolis Kogevinas38, Maria Grigoroiu-Serbanescu39, Peter Propping40, Tim Becker41, Marcella Rietschel7, Markus M Nöthen42, Sven Cichon43.
Abstract
Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common genetic variants involved in disease aetiology. The data also provide strong evidence for the presence of multiple additional risk loci, each contributing a relatively small effect to BD susceptibility. Large samples are necessary to detect these risk loci. Here we present results from the largest BD GWAS to date by investigating 2.3 million single-nucleotide polymorphisms (SNPs) in a sample of 24,025 patients and controls. We detect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk loci ANK3, ODZ4 and TRANK1, as well as the risk locus ADCY2 (5p15.31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD.Entities:
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Year: 2014 PMID： 24618891 DOI： 10.1038/ncomms4339
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919