Literature DB >> 24618871

Sestamibi scintigraphy for parathyroid localisation: a reminder of the dangers of false positives.

Katherine Lisa Whitcroft1, Anup Sharma.   

Abstract

Surgical parathyroidectomy is the only curative treatment for primary hyperparathyroidism. As minimally invasive parathyroidectomy increases in popularity, so does reliance on preoperative parathyroid localisation techniques. One such technique is sestamibi scintigraphy. We report a case of false-positive sestamibi scintigraphy caused by follicular variant of papillary thyroid carcinoma. Subsequent completion thyroidectomy was not possible due to widespread postoperative fibrosis. This case, therefore, highlights the potential dangers of false-positive results due to thyroid carcinoma and encourages surgeons to consider this possibility when faced with intrathyroidal or otherwise ambiguous parathyroid localisation results.

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Year:  2014        PMID: 24618871      PMCID: PMC3962962          DOI: 10.1136/bcr-2013-203225

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  8 in total

Review 1.  Radionuclide imaging of the parathyroid glands.

Authors:  Christopher J Palestro; Maria B Tomas; Gene G Tronco
Journal:  Semin Nucl Med       Date:  2005-10       Impact factor: 4.446

2.  Thyroid cancer detection with dual-isotope parathyroid scintigraphy in primary hyperparathyroidism.

Authors:  Edwin O Onkendi; Melanie L Richards; Geoffrey B Thompson; David R Farley; Patrick J Peller; Clive S Grant
Journal:  Ann Surg Oncol       Date:  2012-03-07       Impact factor: 5.344

3.  Papillary thyroid carcinoma associated with parathyroid adenoma detected by pertechnetate-MIBI subtraction scintigraphy.

Authors:  D Rubello; A Toniato; M R Pelizzo; D Casara
Journal:  Clin Nucl Med       Date:  2000-11       Impact factor: 7.794

4.  The natural history of treated and untreated primary hyperparathyroidism: the parathyroid epidemiology and audit research study.

Authors:  N Yu; G P Leese; D Smith; P T Donnan
Journal:  QJM       Date:  2011-01-25

Review 5.  Synchronous thyroid pathology in patients presenting with primary hyperparathyroidism.

Authors:  Kirt S Beus; Brendan C Stack
Journal:  Am J Otolaryngol       Date:  2004 Sep-Oct       Impact factor: 1.808

6.  Technetium-99m-sestamibi uptake by recurrent Hurthle cell carcinoma of the thyroid.

Authors:  H R Balon; D Fink-BennetT; S S Stoffer
Journal:  J Nucl Med       Date:  1992-07       Impact factor: 10.057

7.  A false-positive localization of a parathyroid adenoma with technetium Tc 99m sestamibi scan secondary to a thyroid follicular carcinoma.

Authors:  W G Koss; M R Brown; J F Balfour
Journal:  Arch Surg       Date:  1996-02

8.  Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS).

Authors:  Ning Yu; Peter T Donnan; Robert W V Flynn; Michael J Murphy; David Smith; Andrew Rudman; Graham P Leese
Journal:  Clin Endocrinol (Oxf)       Date:  2009-12-18       Impact factor: 3.478

  8 in total

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