| Literature DB >> 24618302 |
Gang Zhou1, Pauline C Ting2, Grant Wishart2, Nicolas Zorn2, Robert G Aslanian2, Mingxiang Lin3, Michelle Smith4, Scott S Walker4, John Cook4, Margaret Van Heek4, Jean Lachowicz4.
Abstract
Herein we report the design and synthesis of a series of novel bicyclic DGAT1 inhibitors with a carboxylic acid moiety. The optimization of the initial lead compound 7 based on in vitro and in vivo activity led to the discovery of potent indoline and quinoline classes of DGAT1 inhibitors. The structure-activity relationship studies of these novel series of bicyclic carboxylic acid derivatives as DGAT1 inhibitors are described.Entities:
Keywords: Cyclohexanecarboxylic acid; DGAT1 inhibitor; Diacylglycerol acyltransferase inhibitor; Indoline; Quinoline; Triacylglyceride
Mesh：
Substances：
Year: 2014 PMID： 24618302 DOI： 10.1016/j.bmcl.2014.02.028
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823