Rahmatullah Rahmati1,2, Snjezana Dogan3, Owen Pyke1,4, Frank Palmer1, Mahmoud Awad1, Nancy Lee5, Dennis H Kraus1,6, Jatin P Shah1, Snehal G Patel1, Ian Ganly1. 1. Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York. 2. Department of Otolaryngology-Head and Neck Surgery, Columbia University Medical Center, New York, New York. 3. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York. 4. State University of New York - Stony Brook, School of Medicine, Stony Brook, New York. 5. Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York. 6. Head and Neck Institute, North Shore Health System, Great Neck, New York.
Abstract
BACKGROUND: The purpose of this study was to report the long-term outcome of patients with squamous cell cancer (SCC) of the tonsil managed by surgery followed by postoperative radiotherapy (PORT). METHODS: Eighty-eight patients treated between 1985 and 2005 were analyzed. Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) were determined by the Kaplan-Meier method. Factors predictive of outcome were determined by univariate and multivariate analysis. RESULTS: Forty-eight percent of patients had T3 to T4 disease and 75% had a positive neck. Five-year OS, DSS, and RFS were 66%, 82%, and 80%, respectively. The status of the neck was not predictive of outcome (DSS 80% for N0 vs 82% for N+; p = .97). Lymphovascular invasion was an independent predictor of OS, DSS, and RFS on multivariate analysis. CONCLUSION: Lymphovascular invasion but not pathological stage of the neck is an independent predictor of outcome in patients with tonsillar SCC.
BACKGROUND: The purpose of this study was to report the long-term outcome of patients with squamous cell cancer (SCC) of the tonsil managed by surgery followed by postoperative radiotherapy (PORT). METHODS: Eighty-eight patients treated between 1985 and 2005 were analyzed. Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) were determined by the Kaplan-Meier method. Factors predictive of outcome were determined by univariate and multivariate analysis. RESULTS: Forty-eight percent of patients had T3 to T4 disease and 75% had a positive neck. Five-year OS, DSS, and RFS were 66%, 82%, and 80%, respectively. The status of the neck was not predictive of outcome (DSS 80% for N0 vs 82% for N+; p = .97). Lymphovascular invasion was an independent predictor of OS, DSS, and RFS on multivariate analysis. CONCLUSION: Lymphovascular invasion but not pathological stage of the neck is an independent predictor of outcome in patients with tonsillar SCC.
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