Literature DB >> 24615464

[Cell-based therapy to treat stress urinary incontinence: which cell type at what cost?].

M Vaegler1, L A DaSilva, K Benz, B Amend, J Mollenhauer, W K Aicher, A Stenzl, K-D Sievert.   

Abstract

In Germany, 6-8 million woman and men suffer urinary incontinence, which represents 12.5 % of the population. It is estimated that by the middle of this century, it will increase to almost 30 %. The primary reason will be primarily related to the aging population but also to patient awareness and seeking a solution. In addition to the cost which is covered by the health insurance, the patient will spend more than half a billion euro/year out-of-pocket, not to mention the social stigma associated with urinary incontinence. The current common treatment options are symptomatic but do not restore functionality. One option might be tissue engineering or stem cell therapy. This article describes the likelihood that this therapy will change the approach in treating stress urinary incontinence. Boundaries and legal aspects are highlighted as well as approximated cost. These treatment costs might be currently higher than the standard treatment options, but the investment to reduce these costs are paid indirectly by society.

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Year:  2014        PMID: 24615464     DOI: 10.1007/s00120-013-3353-8

Source DB:  PubMed          Journal:  Urologe A        ISSN: 0340-2592            Impact factor:   0.639


  61 in total

1.  Preliminary results of myoblast injection into the urethra and bladder wall: a possible method for the treatment of stress urinary incontinence and impaired detrusor contractility.

Authors:  M B Chancellor; T Yokoyama; S Tirney; C E Mattes; H Ozawa; N Yoshimura; W C de Groat; J Huard
Journal:  Neurourol Urodyn       Date:  2000       Impact factor: 2.696

Review 2.  Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views.

Authors:  Donald G Phinney; Darwin J Prockop
Journal:  Stem Cells       Date:  2007-09-27       Impact factor: 6.277

Review 3.  Continence and complications rates after male slings as primary surgery for post-prostatectomy incontinence: a systematic review.

Authors:  Maria Angela Cerruto; Carolina D'Elia; Walter Artibani
Journal:  Arch Ital Urol Androl       Date:  2013-06-24

4.  The anatomical components of urinary continence.

Authors:  Christian Wallner; Noshir F Dabhoiwala; Marco C DeRuiter; Wouter H Lamers
Journal:  Eur Urol       Date:  2008-08-20       Impact factor: 20.096

5.  Mesenchymal stem cell transplantation for the infarcted heart: a role in minimizing abnormalities in cardiac-specific energy metabolism.

Authors:  Curtis C Hughey; Virginia L Johnsen; Lianli Ma; Freyja D James; Pampee P Young; David H Wasserman; Jeffrey N Rottman; Dustin S Hittel; Jane Shearer
Journal:  Am J Physiol Endocrinol Metab       Date:  2011-10-04       Impact factor: 4.310

6.  High costs of urinary incontinence among women electing surgery to treat stress incontinence.

Authors:  Leslee L Subak; Linda Brubaker; Toby C Chai; Jennifer M Creasman; Ananias C Diokno; Patricia S Goode; Stephen R Kraus; John W Kusek; Wendy W Leng; Emily S Lukacz; Peggy Norton; Sharon Tennstedt
Journal:  Obstet Gynecol       Date:  2008-04       Impact factor: 7.661

7.  Improved sphincter contractility after allogenic muscle-derived progenitor cell injection into the denervated rat urethra.

Authors:  Tracy W Cannon; Ji Youl Lee; George Somogyi; Ryan Pruchnic; Christopher P Smith; Johnny Huard; Michael B Chancellor
Journal:  Urology       Date:  2003-11       Impact factor: 2.649

8.  Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells.

Authors:  Arianna Dellavalle; Maurilio Sampaolesi; Rossana Tonlorenzi; Enrico Tagliafico; Benedetto Sacchetti; Laura Perani; Anna Innocenzi; Beatriz G Galvez; Graziella Messina; Roberta Morosetti; Sheng Li; Marzia Belicchi; Giuseppe Peretti; Jeffrey S Chamberlain; Woodring E Wright; Yvan Torrente; Stefano Ferrari; Paolo Bianco; Giulio Cossu
Journal:  Nat Cell Biol       Date:  2007-02-11       Impact factor: 28.824

Review 9.  Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head.

Authors:  Lars Rackwitz; Lars Eden; Stephan Reppenhagen; Johannes C Reichert; Franz Jakob; Heike Walles; Oliver Pullig; Rocky S Tuan; Maximilian Rudert; Ulrich Nöth
Journal:  Stem Cell Res Ther       Date:  2012-02-22       Impact factor: 6.832

10.  Mesenchymal stem cells.

Authors:  A I Caplan
Journal:  J Orthop Res       Date:  1991-09       Impact factor: 3.494

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