Marcel G M Olde Rikkert1, Frans R Verhey2, John W C Sijben3, Femke H Bouwman4, Paul L J Dautzenberg5, Mirian Lansink3, Walther M W Sipers6, Dieneke Z B van Asselt7, Anneke M J van Hees3, Martijn Stevens8, Bruno Vellas9, Philip Scheltens10. 1. Radboud Alzheimer Center, Department of Geriatric Medicine, Radboud University Hospital, Nijmegen, The Netherlands. 2. Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands. 3. Nutricia Research, Utrecht, The Netherlands. 4. Neurology Department, Catharina Ziekenhuis, Eindhoven, The Netherlands. 5. Geriatrics Department, Jeroen Bosch Ziekenhuis, 's-Hertogenbosch, The Netherlands. 6. Department of Geriatric Medicine, Orbis Medisch Centrum, Sittard, The Netherlands. 7. Department of Geriatric Medicine, Medical Center Leeuwarden, Leeuwarden, The Netherlands. 8. Neurology Department, Tergooiziekenhuizen Blaricum, Blaricum, The Netherlands. 9. Gerontopole, INSERM U 1027, Toulouse, France. 10. Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands.
Abstract
BACKGROUND: Studies on the systemic availability of nutrients and nutritional status in Alzheimer's disease (AD) are widely available, but the majority included patients in a moderate stage of AD. OBJECTIVE: This study compares the nutritional status between mild AD outpatients and healthy controls. METHODS:A subgroup of Dutch drug-naïve patients with mild AD (Mini-Mental State Examination (MMSE) ≥20) from the Souvenir II randomized controlled study (NTR1975) and a group of Dutch healthy controls were included. Nutritional status was assessed by measuring levels of several nutrients, conducting the Mini Nutritional Assessment (MNA®) questionnaire and through anthropometric measures. RESULTS: In total, data of 93 healthy cognitively intact controls (MMSE 29.0 [23.0-30.0]) and 79 very mild AD patients (MMSE = 25.0 [20.0-30.0]) were included. Plasma selenium (p < 0.001) and uridine (p = 0.046) levels were significantly lower in AD patients, with a similar trend for plasma vitamin D (p = 0.094) levels. In addition, the fatty acid profile in erythrocyte membranes was different between groups for several fatty acids. Mean MNA screening score was significantly lower in AD patients (p = 0.008), but not indicative of malnutrition risk. No significant differences were observed for other micronutrient or anthropometric parameters. CONCLUSION: In non-malnourished patients with very mild AD, lower levels of some micronutrients, a different fatty acid profile in erythrocyte membranes and a slightly but significantly lower MNA screening score were observed. This suggests that subtle differences in nutrient status are present already in a very early stage of AD and in the absence of protein/energy malnutrition.
RCT Entities:
BACKGROUND: Studies on the systemic availability of nutrients and nutritional status in Alzheimer's disease (AD) are widely available, but the majority included patients in a moderate stage of AD. OBJECTIVE: This study compares the nutritional status between mild AD outpatients and healthy controls. METHODS: A subgroup of Dutch drug-naïve patients with mild AD (Mini-Mental State Examination (MMSE) ≥20) from the Souvenir II randomized controlled study (NTR1975) and a group of Dutch healthy controls were included. Nutritional status was assessed by measuring levels of several nutrients, conducting the Mini Nutritional Assessment (MNA®) questionnaire and through anthropometric measures. RESULTS: In total, data of 93 healthy cognitively intact controls (MMSE 29.0 [23.0-30.0]) and 79 very mild ADpatients (MMSE = 25.0 [20.0-30.0]) were included. Plasma selenium (p < 0.001) and uridine (p = 0.046) levels were significantly lower in ADpatients, with a similar trend for plasma vitamin D (p = 0.094) levels. In addition, the fatty acid profile in erythrocyte membranes was different between groups for several fatty acids. Mean MNA screening score was significantly lower in ADpatients (p = 0.008), but not indicative of malnutrition risk. No significant differences were observed for other micronutrient or anthropometric parameters. CONCLUSION: In non-malnourished patients with very mild AD, lower levels of some micronutrients, a different fatty acid profile in erythrocyte membranes and a slightly but significantly lower MNA screening score were observed. This suggests that subtle differences in nutrient status are present already in a very early stage of AD and in the absence of protein/energy malnutrition.
Authors: John E Morley; John C Morris; Marla Berg-Weger; Soo Borson; Brian D Carpenter; Natalia Del Campo; Bruno Dubois; Keith Fargo; L Jaime Fitten; Joseph H Flaherty; Mary Ganguli; George T Grossberg; Theodore K Malmstrom; Ronald D Petersen; Carroll Rodriguez; Andrew J Saykin; Philip Scheltens; Eric G Tangalos; Joe Verghese; Gordon Wilcock; Bengt Winblad; Jean Woo; Bruno Vellas Journal: J Am Med Dir Assoc Date: 2015-09-01 Impact factor: 4.669
Authors: Loreta Strumylaite; Rima Kregzdyte; Odeta Kucikiene; Dale Baranauskiene; Vaida Simakauskiene; Rima Naginiene; Gyte Damuleviciene; Vita Lesauskaite; Reda Zemaitiene Journal: Int J Environ Res Public Health Date: 2022-06-14 Impact factor: 4.614
Authors: Max Herke; Astrid Fink; Gero Langer; Tobias Wustmann; Stefan Watzke; Anne-Marie Hanff; Marion Burckhardt Journal: Cochrane Database Syst Rev Date: 2018-07-18
Authors: Anne Rijpma; Olga Meulenbroek; Anneke M J van Hees; John W C Sijben; Bruno Vellas; Raj C Shah; David A Bennett; Philip Scheltens; Marcel G M Olde Rikkert Journal: Alzheimers Res Ther Date: 2015-07-24 Impact factor: 6.982