Literature DB >> 24614343

Advances in IBD genetics.

Johan Van Limbergen1, Graham Radford-Smith2, Jack Satsangi3.   

Abstract

IBD is a spectrum of chronic disorders that constitute an important health problem worldwide. The hunt for genetic determinants of disease onset and course has culminated in the Immunochip project, which has identified >160 loci containing IBD susceptibility genes. In this Review, we highlight how genetic association studies have informed our understanding of the pathogenesis of IBD by focusing research efforts on key pathways involved in innate immunity, autophagy, lymphocyte differentiation and chemotaxis. Several of these novel genetic markers and cellular pathways are promising candidates for patient stratification and therapeutic targeting.

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Mesh：

Year:  2014        PMID： 24614343     DOI： 10.1038/nrgastro.2014.27

Source DB:  PubMed          Journal:  Nat Rev Gastroenterol Hepatol        ISSN： 1759-5045            Impact factor:   46.802


  54 in total

Review 1.  Autophagy and checkpoints for intracellular pathogen defense.

Authors:  Geraldine L C Paulus; Ramnik J Xavier
Journal:  Curr Opin Gastroenterol       Date:  2015-01       Impact factor: 3.287

Review 2.  Pathway-based approaches to the treatment of inflammatory bowel disease.

Authors:  Giorgos Bamias; Theresa T Pizarro; Fabio Cominelli
Journal:  Transl Res       Date:  2015-09-07       Impact factor: 7.012

Review 3.  Molecular Analysis of Inflammatory Bowel Disease: Clinically Useful Tools for Diagnosis, Response Prediction, and Monitoring of Targeted Therapy.

Authors:  Weiwei Jiang; Xuhang Li
Journal:  Mol Diagn Ther       Date:  2015-06       Impact factor: 4.074

Review 4.  IBD and the gut microbiota--from bench to personalized medicine.

Authors:  Emanuelle Bellaguarda; Eugene B Chang
Journal:  Curr Gastroenterol Rep       Date:  2015-04

Review 5.  Epidemiology and risk factors for IBD.

Authors:  Ashwin N Ananthakrishnan
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2015-03-03       Impact factor: 46.802

Review 6.  Inflammatory Bowel Disease in Primary Immunodeficiencies.

Authors:  Judith R Kelsen; Kathleen E Sullivan
Journal:  Curr Allergy Asthma Rep       Date:  2017-08       Impact factor: 4.806

7.  Multi-locus genetic risk score predicts risk for Crohn's disease in Slovenian population.

Authors:  Katarina Zupančič; Kristijan Skok; Katja Repnik; Rinse K Weersma; Uroš Potočnik; Pavel Skok
Journal:  World J Gastroenterol       Date:  2016-04-14       Impact factor: 5.742

Review 8.  The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions.

Authors:  Stephen M Vindigni; Timothy L Zisman; David L Suskind; Christopher J Damman
Journal:  Therap Adv Gastroenterol       Date:  2016-04-19       Impact factor: 4.409

9.  Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring.

Authors:  Jun Miyoshi; Alexandria M Bobe; Sawako Miyoshi; Yong Huang; Nathaniel Hubert; Tom O Delmont; A Murat Eren; Vanessa Leone; Eugene B Chang
Journal:  Cell Rep       Date:  2017-07-11       Impact factor: 9.423

10.  A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion.

Authors:  Neil Warner; Aaron Burberry; Maria Pliakas; Christine McDonald; Gabriel Núñez
Journal:  J Biol Chem       Date:  2014-08-28       Impact factor: 5.157
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