| Literature DB >> 24613801 |
Sheng-Zhuo Huang1, Xuan Zhang2, Qing-Yun Ma3, Hua Peng4, Yong-Tang Zheng2, Jiang-Miao Hu4, Hao-Fu Dai3, Jun Zhou5, You-Xing Zhao6.
Abstract
Three tigliane-type diterpenoids named excoecafolins A-C and two daphnane-type diterpenoids named excoecafolins D and E, together with 13 known compounds, were isolated from the EtOAc extract of Excoecaria acerifolia Didr. Their structures were elucidated through the analysis of the spectroscopic data. The anti-HIV-1 activity evaluation of five of these compounds showed that four possessed moderate anti-HIV-1 activities with EC50 0.258, 0.036, 0.046, and 0.978 μM, SI >1,836.9, 431.1, 298.7, and >503.7, respectively. Additionally, the chemotaxonomic issue of the affinity correlation between Thymelaeceae and Euphorbiaceae is discussed based on the isolates.Entities:
Keywords: 4-O-methyl-TPA (PubChem CID 72292); Anti-HIV-1; Chemotaxonomy; Euphorbiaceae; Excoecafolin; Excoecaria acerifolia; caryolanel,9β-diol (PubChem CID 44559977); catechin (PubChem CID 9064); daphneticin (PubChem CID 158341); dapneolon (PubChem CID 5316300); excoecariatoxin (PubChem CID 6442008); schisanwilsonene A (PubChem CID 56671370)
Mesh：
Substances：
Year: 2014 PMID： 24613801 DOI： 10.1016/j.fitote.2014.02.018
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882