Literature DB >> 2461363

Structure of the von Willebrand factor domain interacting with glycoprotein Ib.

H Mohri1, Y Fujimura, M Shima, A Yoshioka, R A Houghten, Z M Ruggeri, T S Zimmerman.   

Abstract

von Willebrand factor is a multifunctional adhesive protein of plasma, platelets, and endothelial cells that mediates a crucial interaction for normal hemostasis and thrombus formation by binding to platelet membrane glycoprotein Ib. We provide here evidence that this function involves two limited noncontiguous regions of the molecule, each contained within 15 amino acid residues, separated in the linear sequence by 205 residues, and maintained in close spatial proximity in the folded molecule by disulfide bonding. Definition of this chemical structure clarifies a fundamental mechanism of platelet adhesion to thrombogenic surfaces and sets the bases for obtaining synthetic replicas that may be used to modulate platelet function.

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Year:  1988        PMID： 2461363

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  33 in total

1.  Germ-line mosaicism for a valine-to-methionine substitution at residue 553 in the glycoprotein Ib-binding domain of von Willebrand factor, causing type IIB von Willebrand disease.

Authors:  E W Murray; A R Giles; D Lillicrap
Journal:  Am J Hum Genet       Date:  1992-01       Impact factor: 11.025

2.  Crucial role for the VWF A1 domain in binding to type IV collagen.

Authors:  Veronica H Flood; Abraham C Schlauderaff; Sandra L Haberichter; Tricia L Slobodianuk; Paula M Jacobi; Daniel B Bellissimo; Pamela A Christopherson; Kenneth D Friedman; Joan Cox Gill; Raymond G Hoffmann; Robert R Montgomery
Journal:  Blood       Date:  2015-02-06       Impact factor: 22.113

3.  The linker between the D3 and A1 domains of vWF suppresses A1-GPIbα catch bonds by site-specific binding to the A1 domain.

Authors:  Alexander Tischer; Miguel A Cruz; Matthew Auton
Journal:  Protein Sci       Date:  2013-08       Impact factor: 6.725

Review 4.  14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling.

Authors:  Yunfeng Chen; Zaverio M Ruggeri; Xiaoping Du
Journal:  Blood       Date:  2018-04-05       Impact factor: 22.113

5.  N-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress.

Authors:  Matthew Auton; Katie E Sowa; Molly Behymer; Miguel A Cruz
Journal:  J Biol Chem       Date:  2012-03-19       Impact factor: 5.157

6.  150-kD von Willebrand factor binding protein extracted from human vascular subendothelium is type VI collagen.

Authors:  J H Rand; N D Patel; E Schwartz; S L Zhou; B J Potter
Journal:  J Clin Invest       Date:  1991-07       Impact factor: 14.808

7.  Glycosylation sterically inhibits platelet adhesion to von Willebrand factor without altering intrinsic conformational dynamics.

Authors:  Alexander Tischer; Venkata R Machha; Laurie Moon-Tasson; Linda M Benson; Matthew Auton
Journal:  J Thromb Haemost       Date:  2019-09-03       Impact factor: 5.824

8.  von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure.

Authors:  L Holmberg; J A Dent; R Schneppenheim; U Budde; J Ware; Z M Ruggeri
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

9.  Multi-step binding of ADAMTS-13 to von Willebrand factor.

Authors:  H B Feys; P J Anderson; K Vanhoorelbeke; E M Majerus; J E Sadler
Journal:  J Thromb Haemost       Date:  2009-09-18       Impact factor: 5.824

10.  Limitations of the ristocetin cofactor assay in measurement of von Willebrand factor function.

Authors:  V H Flood; K D Friedman; J C Gill; P A Morateck; J S Wren; J P Scott; R R Montgomery
Journal:  J Thromb Haemost       Date:  2009-08-19       Impact factor: 5.824
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