Jin Ju Kim1, Kyu Ri Hwang2, Young Min Choi3, Shin Yong Moon4, Soo Jin Chae5, Chan Woo Park6, Hye Ok Kim6, Doo Seok Choi7, Hyuck Chan Kwon8, Byung Moon Kang9, Byung Seok Lee10, Si Hyun Cho10, Tai June Kim11, Tak Kim12, Min Ju Kim13, Hyun Young Park13. 1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea; Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea. 2. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea; Department of Obstetrics and Gynecology, Seoul Metropolitan Government (SMG)-Seoul National University (SNU) Boramae Medical Center, Seoul, South Korea. 3. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea; Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: ymchoi@snu.ac.kr. 4. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea; Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea. 5. Department of Obstetrics and Gynecology, Maria Fertility Hospital, Seoul, South Korea. 6. Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea. 7. Department of Obstetrics and Gynecology, Seoul Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea. 8. Department of Obstetrics and Gynecology, Miraewa-heemang Hospital, Seoul, South Korea. 9. Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. 10. Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea. 11. Department of Obstetrics and Gynecology, Mizmedi Women's Hospital, Seoul, South Korea. 12. Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, South Korea. 13. Division of Cardiovascular and Rare Diseases, Korea National Institute of Health, Chungbuk, South Korea.
Abstract
OBJECTIVE: To investigate the complete metabolic and phenotypic profiles of a large cohort of untreated, consecutively recruited Korean women with polycystic ovary syndrome (PCOS), for whom a registry for Korean women with PCOS was constructed. DESIGN: Observational study. SETTING: Three infertility clinics and 10 university hospitals. PATIENT(S): Eight hundred sixty-five women with PCOS were recruited using the Rotterdam criteria. INTERVENTION(S): Standardized evaluation protocol and web-based case report form. MAIN OUTCOME MEASURE(S): Metabolic and phenotypic profiles. RESULT(S): The subjects with PCOS mainly consisted of young and nonobese women. The most problematic subjective symptom was menstrual disturbance or infertility, and, on average, the patients seemed to menstruate every 2 months. PCO morphology was observed in 96.5% of the patients. Although few women visited hospitals owing to HA symptoms alone, hirsutism was observed in one-third of the patients (33.9%) and half (47.4%) of the patients had biochemical HA. About one-fifth (20.1%) of the patients had generalized obesity, and one-third (33.2%) had central obesity. Prevalence of dyslipidemia, diabetes, hypertension, and metabolic syndrome were 35.7%, 3.5%, 4.0%, and 13.7%, respectively. Prevalence of prediabetes was 20.8%, and a substantial proportion of additional subjects with normal fasting plasma glucose or oral glucose tolerance tests were identified as having prediabetes by hemoglobin A1C testing. CONCLUSION(S): Our well-defined cohort provided comprehensive estimates of the features of metabolic and phenotypic profiles related to PCOS in Korean women. Further longitudinal follow-up studies are needed to investigate the changes in phenotypic and metabolic markers in this PCOS cohort.
OBJECTIVE: To investigate the complete metabolic and phenotypic profiles of a large cohort of untreated, consecutively recruited Korean women with polycystic ovary syndrome (PCOS), for whom a registry for Korean women with PCOS was constructed. DESIGN: Observational study. SETTING: Three infertility clinics and 10 university hospitals. PATIENT(S): Eight hundred sixty-five women with PCOS were recruited using the Rotterdam criteria. INTERVENTION(S): Standardized evaluation protocol and web-based case report form. MAIN OUTCOME MEASURE(S): Metabolic and phenotypic profiles. RESULT(S): The subjects with PCOS mainly consisted of young and nonobese women. The most problematic subjective symptom was menstrual disturbance or infertility, and, on average, the patients seemed to menstruate every 2 months. PCO morphology was observed in 96.5% of the patients. Although few women visited hospitals owing to HA symptoms alone, hirsutism was observed in one-third of the patients (33.9%) and half (47.4%) of the patients had biochemical HA. About one-fifth (20.1%) of the patients had generalized obesity, and one-third (33.2%) had central obesity. Prevalence of dyslipidemia, diabetes, hypertension, and metabolic syndrome were 35.7%, 3.5%, 4.0%, and 13.7%, respectively. Prevalence of prediabetes was 20.8%, and a substantial proportion of additional subjects with normal fasting plasma glucose or oral glucose tolerance tests were identified as having prediabetes by hemoglobin A1C testing. CONCLUSION(S): Our well-defined cohort provided comprehensive estimates of the features of metabolic and phenotypic profiles related to PCOS in Korean women. Further longitudinal follow-up studies are needed to investigate the changes in phenotypic and metabolic markers in this PCOS cohort.
Authors: Havagiray R Chitme; Eman A K Al Azawi; Anfal M Al Abri; Buthina M Al Busaidi; Zamzam K A Salam; Maisa M Al Taie; Saja K Al Harbo Journal: J Taibah Univ Med Sci Date: 2017-01-13