| Literature DB >> 24613377 |
Rika Yamada1, Tomoya Takeshita1, Masato Hiraizumi1, Daisuke Shinohe1, Yoshihiro Ohta1, Kaori Sakurai2.
Abstract
OSW-1 is a steroidal saponin, which has emerged as an attractive anticancer agent with highly cancer cell selective activity. A fluorescent analog was prepared from the natural product to analyze its cellular uptake and localization. We found that the fluorescent analog is rapidly internalized into cells and is primarily distributed in endoplasmic reticulum and Golgi apparatus.Entities:
Keywords: Anticancer agent; Cellular localization; Cellular uptake; Fluorescent probe; Steroidal glycoside
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Year: 2014 PMID： 24613377 DOI： 10.1016/j.bmcl.2014.02.009
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823