PURPOSE: To examine the relationship between major ocular diseases and mortality. METHODS: The population-based longitudinal study Beijing Eye Study was performed in 2001 and repeated in 2011. The participants underwent a detailed ophthalmic examination at baseline in 2001. RESULTS: Of 4439 subjects examined in 2001, 2695 (60.7%) subjects returned for the follow-up examination in 2011, while 379 (8.5%) subjects were dead and 1365 (30.8%) subjects were alive, however, did not agree to be re-examined. In multivariate regression analysis, mortality was significantly associated with the systemic parameters of older age (p < 0.001; Odds ratio (OR): 1.07; 95% confidence interval (CI): 1.05, 1.09), male gender (p < 0.001; OR: 0.56; 95% CI: 0.40, 0.78), lower level of education (p < 0.001; OR: 0.66; 95% CI: 0.59, 0.74) and smoking (p < 0.001; OR: 1.84; 95% CI: 1.36, 2.49) and with the ocular parameters of presence of diabetic retinopathy (p = 0.002; OR: 2.26; 95% CI: 1.34, 3.81), non-glaucomatous optic nerve damage (p = 0.001; OR: 4.90; 95% CI: 1.90, 12.7) and higher degree of nuclear cataract (p = 0.002; OR: 1.29; 95% CI: 1.10, 1.52). In that model, mortality was not significantly (all p > 0.05) associated with refractive error, cortical or subcapsular posterior cataract, intraocular pressure, best corrected visual acuity, visual field defects, prevalence of age-related macular degeneration, retinal vein occlusions, open-angle glaucoma and angle-closure glaucoma. CONCLUSIONS: After adjustment for age, gender, level of education and smoking, mortality was significantly higher in subjects with diabetic retinopathy, non-glaucomatous optic nerve damage and nuclear cataract. Other major ophthalmic parameters and disorders such as hyperopia, myopia, high myopia, pterygium, age-related macular degeneration, retinal vein occlusion, glaucoma and cortical or nuclear cataract were not significantly associated with mortality in the multivariate analysis.
PURPOSE: To examine the relationship between major ocular diseases and mortality. METHODS: The population-based longitudinal study Beijing Eye Study was performed in 2001 and repeated in 2011. The participants underwent a detailed ophthalmic examination at baseline in 2001. RESULTS: Of 4439 subjects examined in 2001, 2695 (60.7%) subjects returned for the follow-up examination in 2011, while 379 (8.5%) subjects were dead and 1365 (30.8%) subjects were alive, however, did not agree to be re-examined. In multivariate regression analysis, mortality was significantly associated with the systemic parameters of older age (p < 0.001; Odds ratio (OR): 1.07; 95% confidence interval (CI): 1.05, 1.09), male gender (p < 0.001; OR: 0.56; 95% CI: 0.40, 0.78), lower level of education (p < 0.001; OR: 0.66; 95% CI: 0.59, 0.74) and smoking (p < 0.001; OR: 1.84; 95% CI: 1.36, 2.49) and with the ocular parameters of presence of diabetic retinopathy (p = 0.002; OR: 2.26; 95% CI: 1.34, 3.81), non-glaucomatous optic nerve damage (p = 0.001; OR: 4.90; 95% CI: 1.90, 12.7) and higher degree of nuclear cataract (p = 0.002; OR: 1.29; 95% CI: 1.10, 1.52). In that model, mortality was not significantly (all p > 0.05) associated with refractive error, cortical or subcapsular posterior cataract, intraocular pressure, best corrected visual acuity, visual field defects, prevalence of age-related macular degeneration, retinal vein occlusions, open-angle glaucoma and angle-closure glaucoma. CONCLUSIONS: After adjustment for age, gender, level of education and smoking, mortality was significantly higher in subjects with diabetic retinopathy, non-glaucomatous optic nerve damage and nuclear cataract. Other major ophthalmic parameters and disorders such as hyperopia, myopia, high myopia, pterygium, age-related macular degeneration, retinal vein occlusion, glaucoma and cortical or nuclear cataract were not significantly associated with mortality in the multivariate analysis.
Authors: Carol Y Cheung; Dejiang Xu; Ching-Yu Cheng; Charumathi Sabanayagam; Yih-Chung Tham; Marco Yu; Tyler Hyungtaek Rim; Chew Yian Chai; Bamini Gopinath; Paul Mitchell; Richie Poulton; Terrie E Moffitt; Avshalom Caspi; Jason C Yam; Clement C Tham; Jost B Jonas; Ya Xing Wang; Su Jeong Song; Louise M Burrell; Omar Farouque; Ling Jun Li; Gavin Tan; Daniel S W Ting; Wynne Hsu; Mong Li Lee; Tien Y Wong Journal: Nat Biomed Eng Date: 2020-10-12 Impact factor: 25.671
Authors: Rupal L Shah; Qing Li; Wanting Zhao; Milly S Tedja; J Willem L Tideman; Anthony P Khawaja; Qiao Fan; Seyhan Yazar; Katie M Williams; Virginie J M Verhoeven; Jing Xie; Ya Xing Wang; Moritz Hess; Stefan Nickels; Karl J Lackner; Olavi Pärssinen; Juho Wedenoja; Ginevra Biino; Maria Pina Concas; André Uitterlinden; Fernando Rivadeneira; Vincent W V Jaddoe; Pirro G Hysi; Xueling Sim; Nicholas Tan; Yih-Chung Tham; Sonoko Sensaki; Albert Hofman; Johannes R Vingerling; Jost B Jonas; Paul Mitchell; Christopher J Hammond; René Höhn; Paul N Baird; Tien-Yin Wong; Chinfsg-Yu Cheng; Yik Ying Teo; David A Mackey; Cathy Williams; Seang-Mei Saw; Caroline C W Klaver; Jeremy A Guggenheim; Joan E Bailey-Wilson Journal: Mol Vis Date: 2018-02-05 Impact factor: 2.367