S Sohlberg1, A-K Wikström2, M Olovsson3, P Lindgren4, O Axelsson5, A Mulic-Lutvica6, J Weis7, J Wikström8. 1. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. Electronic address: sara.sohlberg@kbh.uu.se. 2. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. Electronic address: anna-karin.wikstrom@kbh.uu.se. 3. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. Electronic address: matts.olovsson@kbh.uu.se. 4. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. Electronic address: peter.lindgren@kbh.uu.se. 5. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; The Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden. Electronic address: ove.axelsson@kbh.uu.se. 6. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. Electronic address: ajlana.lutvica@kbh.uu.se. 7. Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden. Electronic address: jan.weis@radiol.uu.se. 8. Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden. Electronic address: johan.wikstrom@radiol.uu.se.
Abstract
INTRODUCTION: Preeclampsia affects about 3% of pregnancies and the placenta is believed to play a major role in its pathophysiology. Lately, the role of the placenta has been hypothesised to be more pronounced in preeclampsia of early (<34 weeks) rather than late (≥ 34 weeks) onset. (31)P Magnetic Resonance Spectroscopy (MRS) enables non-invasive, in vivo studies of placental metabolism. Our aim was to study placental energy and membrane metabolism in women with normal pregnancies and those with early and late onset preeclampsia. METHODS: The study population included fourteen women with preeclampsia (five with early onset and nine with late onset preeclampsia) and sixteen women with normal pregnancy (seven with early and nine with late pregnancy). All women underwent a (31)P-MRS examination of the placenta. RESULTS: The phosphodiester (PDE) spectral intensity fraction of the total (31)P signal and the phosphodiester/phosphomonoester (PDE/PME) spectral intensity ratio was higher in early onset preeclampsia than in early normal pregnancy (p = 0.03 and p = 0.02). In normal pregnancy the PDE spectral intensity fraction and the PDE/PME spectral intensity ratio increased with increasing gestational age (p = 0.006 and p = 0.001). DISCUSSION: Since PDE and PME are related to cell membrane degradation and formation, respectively, our findings indicate increased cell degradation and maybe also decreased cell proliferation in early onset preeclampsia compared to early normal pregnancy, and with increasing gestational age in normal pregnancy. CONCLUSIONS: Our findings could be explained by increased apoptosis due to ischaemia in early onset preeclampsia and also increased apoptosis with increasing gestational age in normal pregnancy.
INTRODUCTION: Preeclampsia affects about 3% of pregnancies and the placenta is believed to play a major role in its pathophysiology. Lately, the role of the placenta has been hypothesised to be more pronounced in preeclampsia of early (<34 weeks) rather than late (≥ 34 weeks) onset. (31)P Magnetic Resonance Spectroscopy (MRS) enables non-invasive, in vivo studies of placental metabolism. Our aim was to study placental energy and membrane metabolism in women with normal pregnancies and those with early and late onset preeclampsia. METHODS: The study population included fourteen women with preeclampsia (five with early onset and nine with late onset preeclampsia) and sixteen women with normal pregnancy (seven with early and nine with late pregnancy). All women underwent a (31)P-MRS examination of the placenta. RESULTS: The phosphodiester (PDE) spectral intensity fraction of the total (31)P signal and the phosphodiester/phosphomonoester (PDE/PME) spectral intensity ratio was higher in early onset preeclampsia than in early normal pregnancy (p = 0.03 and p = 0.02). In normal pregnancy the PDE spectral intensity fraction and the PDE/PME spectral intensity ratio increased with increasing gestational age (p = 0.006 and p = 0.001). DISCUSSION: Since PDE and PME are related to cell membrane degradation and formation, respectively, our findings indicate increased cell degradation and maybe also decreased cell proliferation in early onset preeclampsia compared to early normal pregnancy, and with increasing gestational age in normal pregnancy. CONCLUSIONS: Our findings could be explained by increased apoptosis due to ischaemia in early onset preeclampsia and also increased apoptosis with increasing gestational age in normal pregnancy.
Authors: Rachel S Kelly; Rachel T Giorgio; Bo L Chawes; Natalia I Palacios; Kathryn J Gray; Hoooman Mirzakhani; Ann Wu; Kevin Blighe; Scott T Weiss; Jessica Lasky-Su Journal: Metabolomics Date: 2017-06-12 Impact factor: 4.290
Authors: Stefan Markovic; Anne Fages; Tangi Roussel; Ron Hadas; Alexander Brandis; Michal Neeman; Lucio Frydman Journal: Proc Natl Acad Sci U S A Date: 2018-02-14 Impact factor: 11.205
Authors: Stephanie A Giza; Simran Sethi; Lauren M Smith; Mary-Ellen E T Empey; Lindsay E Morris; Charles A McKenzie Journal: J Dev Orig Health Dis Date: 2020-12-14 Impact factor: 2.401
Authors: T Cindrova-Davies; M Tissot van Patot; L Gardner; E Jauniaux; G J Burton; D S Charnock-Jones Journal: Mol Hum Reprod Date: 2014-11-11 Impact factor: 4.025
Authors: Miriam W Lagemaat; Bart L van de Bank; Pascal Sati; Shizhe Li; Marnix C Maas; Tom W J Scheenen Journal: NMR Biomed Date: 2015-12-08 Impact factor: 4.044